Publication

Inflammatory lung edema correlates with echocardiographic estimation of capillary wedge pressure in newly diagnosed septic patients

Santos, T. M., Franci, D., Gontijo-Coutinho, C. M., Ozahata, T. M., de Araújo Guerra Grangeia, T., Matos-Souza, J. R. & Carvalho-Filho, M. A., Apr-2018, In : Journal of Critical Care. 44, p. 392-397 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Santos, T. M., Franci, D., Gontijo-Coutinho, C. M., Ozahata, T. M., de Araújo Guerra Grangeia, T., Matos-Souza, J. R., & Carvalho-Filho, M. A. (2018). Inflammatory lung edema correlates with echocardiographic estimation of capillary wedge pressure in newly diagnosed septic patients. Journal of Critical Care, 44, 392-397. https://doi.org/10.1016/j.jcrc.2017.11.036

Author

Santos, Thiago M ; Franci, Daniel ; Gontijo-Coutinho, Carolina M ; Ozahata, Tatiana Mirabetti ; de Araújo Guerra Grangeia, Tiago ; Matos-Souza, José R ; Carvalho-Filho, Marco A. / Inflammatory lung edema correlates with echocardiographic estimation of capillary wedge pressure in newly diagnosed septic patients. In: Journal of Critical Care. 2018 ; Vol. 44. pp. 392-397.

Harvard

Santos, TM, Franci, D, Gontijo-Coutinho, CM, Ozahata, TM, de Araújo Guerra Grangeia, T, Matos-Souza, JR & Carvalho-Filho, MA 2018, 'Inflammatory lung edema correlates with echocardiographic estimation of capillary wedge pressure in newly diagnosed septic patients', Journal of Critical Care, vol. 44, pp. 392-397. https://doi.org/10.1016/j.jcrc.2017.11.036

Standard

Inflammatory lung edema correlates with echocardiographic estimation of capillary wedge pressure in newly diagnosed septic patients. / Santos, Thiago M; Franci, Daniel; Gontijo-Coutinho, Carolina M; Ozahata, Tatiana Mirabetti; de Araújo Guerra Grangeia, Tiago; Matos-Souza, José R; Carvalho-Filho, Marco A.

In: Journal of Critical Care, Vol. 44, 04.2018, p. 392-397.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Santos TM, Franci D, Gontijo-Coutinho CM, Ozahata TM, de Araújo Guerra Grangeia T, Matos-Souza JR et al. Inflammatory lung edema correlates with echocardiographic estimation of capillary wedge pressure in newly diagnosed septic patients. Journal of Critical Care. 2018 Apr;44:392-397. https://doi.org/10.1016/j.jcrc.2017.11.036


BibTeX

@article{ba07db084e91457a962b592cdc8e64d2,
title = "Inflammatory lung edema correlates with echocardiographic estimation of capillary wedge pressure in newly diagnosed septic patients",
abstract = "PURPOSE: Lung ultrasound is an accurate and accessible tool to quantify lung edema. Furthermore, left ventricle filling pressures (LVFP) can be assessed with transthoracic echocardiography (TTE) by the E/e' ratio (E/e'). The present study aimed to assess the correlation between E/e' and lung edema quantified by a simplified lung ultrasound score (LUS) in newly admitted septic patients.MATERIALS AND METHODS: In this prospective observational cohort, septic adult patients admitted at the emergency department of a tertiary hospital were included. LUS consisted of four different patterns of lung edema (from normal aeration to parenchymal consolidation). To compare lung edema with LVFP, E/e' was calculated immediately before or within 5min of fluid therapy.RESULTS: Fifty patients were enrolled in 3months. The LUS correlated with E/e' (r=0.58, P<0.0001). The LUS also increased among E/e' quartiles (Q) (Q1: E/e'≤4.49; Q2: 4.49<E/e'≤5.49; Q3: 5.49<E/e'≤7.11; Q4: >7.11; P=0.0003 for Q1 and 4; 2 and 4); and LUS was significantly higher in abnormal (≥8) vs. normal (<8) values of E/e' (11.29 vs 8.49, P=0.007).CONCLUSION: In newly admitted septic patients, lung edema is positively correlated with LVFP prior to fluid therapy. This finding might help find future targets for fluid resuscitation in sepsis.",
keywords = "Journal Article, Echocardiography, Ultrasound, Lung edema, Emergency department, Tissue Doppler imaging, RESPIRATORY-DISTRESS-SYNDROME, VENTRICULAR DIASTOLIC FUNCTION, GOAL-DIRECTED RESUSCITATION, CHEST-X-RAY, COMPUTED-TOMOGRAPHY, FILLING PRESSURES, BERLIN DEFINITION, PULMONARY-ARTERY, FLUID BALANCE, sepsis, injury",
author = "Santos, {Thiago M} and Daniel Franci and Gontijo-Coutinho, {Carolina M} and Ozahata, {Tatiana Mirabetti} and {de Ara{\'u}jo Guerra Grangeia}, Tiago and Matos-Souza, {Jos{\'e} R} and Carvalho-Filho, {Marco A}",
note = "Copyright {\circledC} 2017 Elsevier Inc. All rights reserved.",
year = "2018",
month = "4",
doi = "10.1016/j.jcrc.2017.11.036",
language = "English",
volume = "44",
pages = "392--397",
journal = "Journal of Critical Care",
issn = "0883-9441",
publisher = "W B SAUNDERS CO-ELSEVIER INC",

}

RIS

TY - JOUR

T1 - Inflammatory lung edema correlates with echocardiographic estimation of capillary wedge pressure in newly diagnosed septic patients

AU - Santos, Thiago M

AU - Franci, Daniel

AU - Gontijo-Coutinho, Carolina M

AU - Ozahata, Tatiana Mirabetti

AU - de Araújo Guerra Grangeia, Tiago

AU - Matos-Souza, José R

AU - Carvalho-Filho, Marco A

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2018/4

Y1 - 2018/4

N2 - PURPOSE: Lung ultrasound is an accurate and accessible tool to quantify lung edema. Furthermore, left ventricle filling pressures (LVFP) can be assessed with transthoracic echocardiography (TTE) by the E/e' ratio (E/e'). The present study aimed to assess the correlation between E/e' and lung edema quantified by a simplified lung ultrasound score (LUS) in newly admitted septic patients.MATERIALS AND METHODS: In this prospective observational cohort, septic adult patients admitted at the emergency department of a tertiary hospital were included. LUS consisted of four different patterns of lung edema (from normal aeration to parenchymal consolidation). To compare lung edema with LVFP, E/e' was calculated immediately before or within 5min of fluid therapy.RESULTS: Fifty patients were enrolled in 3months. The LUS correlated with E/e' (r=0.58, P<0.0001). The LUS also increased among E/e' quartiles (Q) (Q1: E/e'≤4.49; Q2: 4.49<E/e'≤5.49; Q3: 5.49<E/e'≤7.11; Q4: >7.11; P=0.0003 for Q1 and 4; 2 and 4); and LUS was significantly higher in abnormal (≥8) vs. normal (<8) values of E/e' (11.29 vs 8.49, P=0.007).CONCLUSION: In newly admitted septic patients, lung edema is positively correlated with LVFP prior to fluid therapy. This finding might help find future targets for fluid resuscitation in sepsis.

AB - PURPOSE: Lung ultrasound is an accurate and accessible tool to quantify lung edema. Furthermore, left ventricle filling pressures (LVFP) can be assessed with transthoracic echocardiography (TTE) by the E/e' ratio (E/e'). The present study aimed to assess the correlation between E/e' and lung edema quantified by a simplified lung ultrasound score (LUS) in newly admitted septic patients.MATERIALS AND METHODS: In this prospective observational cohort, septic adult patients admitted at the emergency department of a tertiary hospital were included. LUS consisted of four different patterns of lung edema (from normal aeration to parenchymal consolidation). To compare lung edema with LVFP, E/e' was calculated immediately before or within 5min of fluid therapy.RESULTS: Fifty patients were enrolled in 3months. The LUS correlated with E/e' (r=0.58, P<0.0001). The LUS also increased among E/e' quartiles (Q) (Q1: E/e'≤4.49; Q2: 4.49<E/e'≤5.49; Q3: 5.49<E/e'≤7.11; Q4: >7.11; P=0.0003 for Q1 and 4; 2 and 4); and LUS was significantly higher in abnormal (≥8) vs. normal (<8) values of E/e' (11.29 vs 8.49, P=0.007).CONCLUSION: In newly admitted septic patients, lung edema is positively correlated with LVFP prior to fluid therapy. This finding might help find future targets for fluid resuscitation in sepsis.

KW - Journal Article

KW - Echocardiography

KW - Ultrasound

KW - Lung edema

KW - Emergency department

KW - Tissue Doppler imaging

KW - RESPIRATORY-DISTRESS-SYNDROME

KW - VENTRICULAR DIASTOLIC FUNCTION

KW - GOAL-DIRECTED RESUSCITATION

KW - CHEST-X-RAY

KW - COMPUTED-TOMOGRAPHY

KW - FILLING PRESSURES

KW - BERLIN DEFINITION

KW - PULMONARY-ARTERY

KW - FLUID BALANCE

KW - sepsis

KW - injury

U2 - 10.1016/j.jcrc.2017.11.036

DO - 10.1016/j.jcrc.2017.11.036

M3 - Article

VL - 44

SP - 392

EP - 397

JO - Journal of Critical Care

JF - Journal of Critical Care

SN - 0883-9441

ER -

ID: 54436111