Inflammation in older subjects with early- and late-onset depression in the NESDO study: A cross-sectional and longitudinal case-only design

Rozing, M. P., Veerhuis, R., Westendorp, R. G. J., Eikelenboom, P., Stek, M., Marijnissen, R. M., Voshaar, R. C. O., Comijs, H. C. & van Exel, E., Jan-2019, In : Psychoneuroendocrinology. 99, p. 20-27 8 p.

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  • Inflammation in older subjects with early- and late-onset depression

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  • M. P. Rozing
  • R. Veerhuis
  • R. G. J. Westendorp
  • P. Eikelenboom
  • M. Stek
  • R. M. Marijnissen
  • R. C. Oude Voshaar
  • H. C. Comijs
  • E. van Exel

Objective: Different biological mechanisms may underlie depression beginning in early life (early-onset) and depression beginning later in life (late-onset). Although the relation between inflammation and depression has been studied extensively, the distinct role of inflammation in early and late-onset depression in older patients has not been addressed before. In the cross-sectional part of this study, we explored differences in levels of circulating inflammatory markers and cytokine levels in lipopolysaccharide (LPS) stimulated whole blood between older subjects with a late-life onset depression (>= 60 years) and older subjects with an early-onset depression (<60 years). Secondly, in a 2-year follow-up study, we examined if circulating and stimulated inflammatory markers influenced the change in Inventory of Depressive Symptomatology (IDS) scores, and if this relation was different for early-and late-onset depression.

Methods: The study was part of the Netherlands Study of Depression in Older Persons (NESDO). We included 350 patients, all aged 60 and older, with a depressive episode in the previous 6 months: 119 with a late-onset depression and 231 with an early-onset depression. Blood samples were collected and CRP, IL-6, NGAL, GDF15, and, LPS plasma levels were determined and whole blood was LPS stimulated and cytokine levels IL-1 beta, IL-6, TNF alpha, IFN gamma, IL-10, and IL-1 receptor antagonist (IL-ira) were determined.

Results: After adjustment for demographics, health indicators, and medication use, increased plasma CRP levels were more strongly associated with late-onset depression than early-onset depression (OR [95% CI]: 1.43 [1.05–1.94]). In the longitudinal analyses, higher circulating IL-6 levels were associated with a significantly slower decline in IDS scores in the crude and the adjusted models (p ≤ 0.027). This relation was not different between late- and early-onset depression. Other circulating and stimulated inflammatory markers were not associated with late- and/or early-onset depression.

Conclusions: This study provides preliminary evidence that low-grade inflammation is more strongly associated with late-onset than early-onset depression in older adults, suggesting a distinct inflammatory etiology for late onset depression. Cytokine production capacity did not distinguish between early- and late-onset depression.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
Publication statusPublished - Jan-2019



ID: 64807290