Publication

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

Holtman, I. R., Raj, D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., Hol, E. M., Boddeke, E. W. G. M. & Eggen, B. J. L., 2015, In : Acta neuropathologica communications. 3, 18 p., 31.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

DOI

INTRODUCTION: Microglia are tissue macrophages of the central nervous system that monitor brain homeostasis and react upon neuronal damage and stress. Aging and neurodegeneration induce a hypersensitive, pro-inflammatory phenotype, referred to as primed microglia. To determine the gene expression signature of priming, the transcriptomes of microglia in aging, Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) mouse models were compared using Weighted Gene Co-expression Network Analysis (WGCNA).

RESULTS: A highly consistent consensus transcriptional profile of up-regulated genes was identified, which prominently differed from the acute inflammatory gene network induced by lipopolysaccharide (LPS). Where the acute inflammatory network was significantly enriched for NF-κB signaling, the primed microglia profile contained key features related to phagosome, lysosome, antigen presentation, and AD signaling. In addition, specific signatures for aging, AD, and ALS were identified.

CONCLUSION: Microglia priming induces a highly conserved transcriptional signature with aging- and disease-specific aspects.

Original languageEnglish
Article number31
Number of pages18
JournalActa neuropathologica communications
Volume3
Publication statusPublished - 2015

Download statistics

No data available

ID: 20713279