Individual depressive symptoms and all-cause mortality In 6673 patients with myocardial infarction: Heterogeneity across age and sex subgroups

Azevedo, R. D. M., Roest, A. M., Carney, R. M., Freedland, K. E., Lane, D. A., Parakh, K., de Jonge, P. & Denollet, J., 1-Mar-2018, In : Journal of Affective Disorders. 228, p. 178-185 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard


  • Individual depressive symptoms and all-cause mortality In 6673 patients with myocardial infarction

    Final publisher's version, 215 KB, PDF document

    Request copy


Background: Depression predicts poor prognosis in patients with myocardial infarction (MI). However, individual depressive symptoms may have different prognostic value, and age and sex could be important effect modifiers. This study compared the prognostic value of individual depressive symptoms across age and sex subgroups in post-MI patients.

Methods: Individual patient-data were compiled for 6673 post-MI patients from seven studies. Depressive symptoms were measured with 10 items of the Beck Depression Inventory (BDI10). The endpoint was all-cause mortality (mean= 3.8 years). Multilevel multivariable Cox regression analysis was used to estimate the mortality risk across age groups (= 55, 56-69 and = 70 years) and sex for symptoms that potentially interacted with age and sex.

Results: At follow-up, 995 (15%) post-MI patients had died. BDI10 depression scores were associated with an increased mortality risk (HR: 1.20; 95% CI: 1.11-1.28, p 70. Fatigue was associated with mortality in women aged 56-69 (HR: 1.54; 1.09-2.15; p=. 012), and suicidal ideation in women aged > 70 (HR: 1.58; 1.03-2.43; p=. 037). Left-ventricular ejection fraction (LVEF) accounted for much of the associations in men = 70 years. Limitations: Findings are sample-specific and need replication in future research; BDI10 items were derived from the original BDI assessment.

Conclusions: There is large heterogeneity in the prognostic value of individual depressive symptoms in post-MI patients across sex and age subgroups. LVEF partially explained the depression-prognosis association in specific subgroups.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalJournal of Affective Disorders
Publication statusPublished - 1-Mar-2018



ID: 52667780