Publication

Independent predictors of poor vitamin K antagonist control in venous thromboembolism patients Data from the EINSTEIN-DVT and PE studies

Kooistra, H. A. M., Gebel, M., Sahin, K., Lensing, A. W. A. & Meijer, K., Dec-2015, In : Thrombosis and Haemostasis. 114, 6, p. 1136-1143 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Kooistra, H. A. M., Gebel, M., Sahin, K., Lensing, A. W. A., & Meijer, K. (2015). Independent predictors of poor vitamin K antagonist control in venous thromboembolism patients Data from the EINSTEIN-DVT and PE studies. Thrombosis and Haemostasis, 114(6), 1136-1143. https://doi.org/10.1160/TH14-12-1033

Author

Kooistra, Hilde A. M. ; Gebel, Martin ; Sahin, Kurtulus ; Lensing, Anthonie W. A. ; Meijer, Karina. / Independent predictors of poor vitamin K antagonist control in venous thromboembolism patients Data from the EINSTEIN-DVT and PE studies. In: Thrombosis and Haemostasis. 2015 ; Vol. 114, No. 6. pp. 1136-1143.

Harvard

Kooistra, HAM, Gebel, M, Sahin, K, Lensing, AWA & Meijer, K 2015, 'Independent predictors of poor vitamin K antagonist control in venous thromboembolism patients Data from the EINSTEIN-DVT and PE studies', Thrombosis and Haemostasis, vol. 114, no. 6, pp. 1136-1143. https://doi.org/10.1160/TH14-12-1033

Standard

Independent predictors of poor vitamin K antagonist control in venous thromboembolism patients Data from the EINSTEIN-DVT and PE studies. / Kooistra, Hilde A. M.; Gebel, Martin; Sahin, Kurtulus; Lensing, Anthonie W. A.; Meijer, Karina.

In: Thrombosis and Haemostasis, Vol. 114, No. 6, 12.2015, p. 1136-1143.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Kooistra HAM, Gebel M, Sahin K, Lensing AWA, Meijer K. Independent predictors of poor vitamin K antagonist control in venous thromboembolism patients Data from the EINSTEIN-DVT and PE studies. Thrombosis and Haemostasis. 2015 Dec;114(6):1136-1143. https://doi.org/10.1160/TH14-12-1033


BibTeX

@article{91aa7f87bee74d12997e51b073f596d4,
title = "Independent predictors of poor vitamin K antagonist control in venous thromboembolism patients Data from the EINSTEIN-DVT and PE studies",
abstract = "Vitamin K antagonists (VKA) are used to prevent recurrent disease in patients with venous thromboembolism (VTE). Their efficacy and safety depend on individual time in therapeutic range (iTTR) and variability of International Normalised Ratios (INR). We aimed to identify independent predictors of poor VKA control > 28 days. In a prospective cohort of 3825 VTE patients, separate logistic regression analyses were performed to identify predictors of low iTTR (first quartile) and instability (iTTR median). Subsequently, the association between these predictors and clinical outcomes was investigated. Weight <50 kg (odds ratio [OR]=1.89; 95 % confidence interval [CI] 1.03-3.49), active cancer at baseline (OR=1.52; CI1.05-2.19), secondary VTE (OR=1.42; CI1.20-1.68), and INR <2.0 at stop of double therapy (OR=1.35; CI1.09-1.67) were independent predictors of low iTTR. The first two were also predictive for instability (OR= 1.96; CI1.06-3.63 and OR=1.95; CI1.36-2.80, re-spectively). ORs of early ( 28 days, which showed some similarities but did not fully overlap. Early VKA control was of additional value for prediction of both, but had to be interpreted in the context of VKA type.",
keywords = "Venous thrombosis, vitamin K antagonists, predictors, iTTR, instability, NORMALIZED RATIO VARIABILITY, STABLE INR CONTROL, ATRIAL-FIBRILLATION, ANTICOAGULATION CONTROL, ORAL ANTICOAGULATION, THROMBOTIC EVENTS, SAME-TT2R2 SCORE, WARFARIN, OUTCOMES, QUALITY",
author = "Kooistra, {Hilde A. M.} and Martin Gebel and Kurtulus Sahin and Lensing, {Anthonie W. A.} and Karina Meijer",
year = "2015",
month = dec,
doi = "10.1160/TH14-12-1033",
language = "English",
volume = "114",
pages = "1136--1143",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "GEORG THIEME VERLAG KG",
number = "6",

}

RIS

TY - JOUR

T1 - Independent predictors of poor vitamin K antagonist control in venous thromboembolism patients Data from the EINSTEIN-DVT and PE studies

AU - Kooistra, Hilde A. M.

AU - Gebel, Martin

AU - Sahin, Kurtulus

AU - Lensing, Anthonie W. A.

AU - Meijer, Karina

PY - 2015/12

Y1 - 2015/12

N2 - Vitamin K antagonists (VKA) are used to prevent recurrent disease in patients with venous thromboembolism (VTE). Their efficacy and safety depend on individual time in therapeutic range (iTTR) and variability of International Normalised Ratios (INR). We aimed to identify independent predictors of poor VKA control > 28 days. In a prospective cohort of 3825 VTE patients, separate logistic regression analyses were performed to identify predictors of low iTTR (first quartile) and instability (iTTR median). Subsequently, the association between these predictors and clinical outcomes was investigated. Weight <50 kg (odds ratio [OR]=1.89; 95 % confidence interval [CI] 1.03-3.49), active cancer at baseline (OR=1.52; CI1.05-2.19), secondary VTE (OR=1.42; CI1.20-1.68), and INR <2.0 at stop of double therapy (OR=1.35; CI1.09-1.67) were independent predictors of low iTTR. The first two were also predictive for instability (OR= 1.96; CI1.06-3.63 and OR=1.95; CI1.36-2.80, re-spectively). ORs of early ( 28 days, which showed some similarities but did not fully overlap. Early VKA control was of additional value for prediction of both, but had to be interpreted in the context of VKA type.

AB - Vitamin K antagonists (VKA) are used to prevent recurrent disease in patients with venous thromboembolism (VTE). Their efficacy and safety depend on individual time in therapeutic range (iTTR) and variability of International Normalised Ratios (INR). We aimed to identify independent predictors of poor VKA control > 28 days. In a prospective cohort of 3825 VTE patients, separate logistic regression analyses were performed to identify predictors of low iTTR (first quartile) and instability (iTTR median). Subsequently, the association between these predictors and clinical outcomes was investigated. Weight <50 kg (odds ratio [OR]=1.89; 95 % confidence interval [CI] 1.03-3.49), active cancer at baseline (OR=1.52; CI1.05-2.19), secondary VTE (OR=1.42; CI1.20-1.68), and INR <2.0 at stop of double therapy (OR=1.35; CI1.09-1.67) were independent predictors of low iTTR. The first two were also predictive for instability (OR= 1.96; CI1.06-3.63 and OR=1.95; CI1.36-2.80, re-spectively). ORs of early ( 28 days, which showed some similarities but did not fully overlap. Early VKA control was of additional value for prediction of both, but had to be interpreted in the context of VKA type.

KW - Venous thrombosis

KW - vitamin K antagonists

KW - predictors

KW - iTTR

KW - instability

KW - NORMALIZED RATIO VARIABILITY

KW - STABLE INR CONTROL

KW - ATRIAL-FIBRILLATION

KW - ANTICOAGULATION CONTROL

KW - ORAL ANTICOAGULATION

KW - THROMBOTIC EVENTS

KW - SAME-TT2R2 SCORE

KW - WARFARIN

KW - OUTCOMES

KW - QUALITY

U2 - 10.1160/TH14-12-1033

DO - 10.1160/TH14-12-1033

M3 - Article

VL - 114

SP - 1136

EP - 1143

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 6

ER -

ID: 34460594