Increased serum levels of anti-angiogenic factors soluble fms-like tyrosine kinase and soluble endoglin in sickle cell disease

Landburg, P. P., Elsenga, H., Schnog, J. B., Duits, A. J. & CURAMA study group, 2008, In : ACTA HAEMATOLOGICA. 120, 3, p. 130-133 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

The anti-angiogenic factors soluble fms-like tyrosine kinase (sFlt)-1 and soluble endoglin (sEng) have been shown to be of importance in angiogenesis by sequestering and inhibiting vascular endothelial growth factor, placenta-like growth factor and transforming growth factor-beta(1) signaling. Given the potential role of angiogenesis in the pathophysiology of sickle cell disease (SCD)-related complications, serum levels of sFlt-1 and sEng were determined in SCD patients and controls. Both sFlt-1 (p = 0.002) and sEng (p = 0.004) were elevated in patients during clinically asymptomatic SCD with no further increment during painful crisis. These data suggest that sFlt-1 and sEng may be important in the regulation of angiogenesis in SCD.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
Issue number3
Publication statusPublished - 2008


  • Anemia, Sickle Cell, Angiogenesis Inhibitors, Antigens, CD, Female, Humans, Male, Neovascularization, Pathologic, Receptors, Cell Surface, Signal Transduction, Transforming Growth Factor beta1, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1

ID: 31176971