Publication

Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins

Hannukainen, J. C., Nuutila, P., Borra, R., Kaprio, J., Kujala, U. M., Janatuinen, T., Heinonen, O. J., Kapanen, J., Viljanen, T., Haaparanta, M., Ronnemaa, T., Parkkola, R., Knuuti, J. & Kalliokoski, K. K., 1-Jan-2007, In : Journal of physiology-London. 578, 1, p. 347-358 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins

    Final publisher's version, 216 KB, PDF document

DOI

  • Jarna C. Hannukainen
  • Pirjo Nuutila
  • Ronald Borra
  • Jaakko Kaprio
  • Urho M. Kujala
  • Tuula Janatuinen
  • Olli J. Heinonen
  • Jukka Kapanen
  • Tapio Viljanen
  • Merja Haaparanta
  • Tapani Ronnemaa
  • Riitta Parkkola
  • Juhani Knuuti
  • Kari K. Kalliokoski

Exercise is considered to be beneficial for free fatty acid (FFA) metabolism, although reports of the effects of increased physical activity on FFA uptake and oxidation in different tissues in vivo in humans have been inconsistent. To investigate the heredity-independent effects of physical activity and fitness on FFA uptake in skeletal muscle, the myocardium, and liver we used positron emission tomography (PET) in nine healthy young male monozygotic twin pairs discordant for physical activity and fitness. The cotwins with higher physical activity constituting the more active group had a similar body mass index but less body fat and 18 +/- 10% higher (V) over circle (O2,max) (P <0.001) compared to the less active brothers with lower physical activity. Low-intensity knee-extension exercise increased skeletal muscle FFA and oxygen uptake six to 10 times compared to resting values but no differences were observed between the groups at rest or during exercise. At rest the more active group had lower hepatic FFA uptake compared to the less active group (5.5 +/- 4.3 versus 9.0 +/- 6.1 mu mol (100 ml)(-1) min(-1), P = 0.04). Hepatic FFA uptake associated significantly with body fat percentage (P = 0.05). Myocardial FFA uptake was similar between the groups. In conclusion, in the absence of the confounding effects of genetic factors, moderately increased physical activity and aerobic fitness decrease body adiposity even in normal-weighted healthy young adult men. Further, increased physical activity together with decreased intra-abdominal adiposity seems to decrease hepatic FFA uptake but has no effects on skeletal muscle or myocardial FFA uptake.

Original languageEnglish
Pages (from-to)347-358
Number of pages12
JournalJournal of physiology-London
Volume578
Issue number1
Publication statusPublished - 1-Jan-2007

    Keywords

  • POSITRON-EMISSION-TOMOGRAPHY, MODERATE-INTENSITY EXERCISE, STIMULATED GLUCOSE-UPTAKE, MYOCARDIAL BLOOD-FLOW, ENDURANCE-TRAINED MEN, SKELETAL-MUSCLE, INSULIN-RESISTANCE, ADIPOSE-TISSUE, DILATED CARDIOMYOPATHY, SUBSTRATE UTILIZATION

ID: 72363449