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Increased neutrophil expression of pattern recognition receptors during COPD exacerbations

Pouwels, S. D., Van Geffen, W. H., Jonker, M. R., Kerstjens, H. A. M., Nawijn, M. C. & Heijink, I. H., Feb-2017, In : Respirology. 22, 2, p. 401-404 4 p.

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  • Increased neutrophil expression of pattern recognition receptors during COPD exacerbations

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DOI

Previously, we observed increased serum levels of damage-associated molecular patterns (DAMPs) during COPD exacerbations. Here, gene expression of DAMP receptors was measured in peripheral blood neutrophils of COPD patients during stable disease and severe acute exacerbation. The expression of toll-like receptor (TLR) 2, TLR4 and NLR family, pyrin domain-containing 3 (NLRP3) was significantly increased, while serum levels of the soluble form of the decoy receptor for advanced glycation end-product (sRAGE) were decreased during exacerbation. Together, these data indicate that increased DAMP signalling contributes to activation of neutrophils during COPD exacerbations.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalRespirology
Volume22
Issue number2
Publication statusPublished - Feb-2017

    Keywords

  • chronic obstructive pulmonary disease, neutrophils, pattern recognition receptors, receptor for advanced glycation end-product, toll-like receptors, OBSTRUCTIVE PULMONARY-DISEASE, BRONCHIAL EPITHELIAL-CELLS, TOLL-LIKE RECEPTORS, CIGARETTE-SMOKE, INNATE, RESPONSES

ID: 36028775