Increased Incidence of T-Cell Malignancies in Patients with Chronic Lymphocytic Leukemia

Choi, G., van den Broek, E. C., Stam, O. CG., van Noesel, C. J. M., Tonino, S. H. & Kater, A. P., 19-Jan-2015, In : Annals of Hematology & Oncology. 2, 2, 2 p., 1023 .

Research output: Contribution to journalArticleAcademicpeer-review

  • Goda Choi
  • Esther C van den Broek
  • Olga CG Stam
  • C.J.M. van Noesel
  • Sanne H. Tonino
  • Armon P. Kater
We present a patient with chemotherapy-refractory Chronic Lymphocytic
Leukemia (CLL) in whom postmortem examination showed hepatosplenomegaly,
with both multiple small-cellular CLL lesions and large-cellular, monoclonal
T-cell infiltrates. Following this case, the co-incidence of T-cell malignancies and
CLL was studied using Dutch and American cancer registry databases. Analysis
showed an excess risk for T-cell malignancies in CLL patients, with increased
standardized incidence ratios compared with the general population and all
cancer survivors in the databases. We hypothesize that CLL cells interact with
T-cells in the microenvironment, facilitating malignant transformation
Original languageEnglish
Article number1023
Number of pages2
JournalAnnals of Hematology & Oncology
Issue number2
Publication statusPublished - 19-Jan-2015


  • Chronic lymphocytic leukemia, T-cell lymphoma, Neoplastic cell transformation, Cohort studies

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