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Incidental congenital coronary artery vascular fistulas in adults: Evaluation with adenosine-N-13-ammonia PET-CT

Said, S. A. M., Agool, A., Moons, A. H. M., Basalus, M. W. Z., Wagenaar, N. R. L., Nijhuis, R. L. G., Schroeder-Tanka, J. M. & Slart, R. H. J. A., 26-Oct-2018, In : World Journal of Cardiology. 10, 10, p. 153-164 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Salah A. M. Said
  • Aly Agool
  • Arno H. M. Moons
  • Mounir W. Z. Basalus
  • Nils R. L. Wagenaar
  • Rogier L. G. Nijhuis
  • Jutta M. Schroeder-Tanka
  • Riemer H. J. A. Slart

AIM

To assess the functionality of congenital coronary artery fistulas (CAFs) using adenosine stress N-13-ammonia positron emission tomography computed tomography (PET-CT).

METHODS

Congenital CAFs were incidentally detected during coronary angiography (CAG) procedures in 11 adult patients (six males and five females) with a mean age of 64.3 years (range 41-81). Patients were collected from three institutes in the Netherlands. The characteristics of the fistulas (origin, pathway and termination), multiplicity of the origins and pathways of the fistulous vessels were assessed by CAG. Five patients underwent adenosine pharmacologic stress N-13-ammonia PET-CT to assess myocardial perfusion and the functional behavior of the fistula.

RESULTS

Eleven patients with 12 CAFs, 10 unilateral and one bilateral, originating from the left anterior descending coronary artery (n = 8), right coronary artery (n = 2) and circumflex (n = 2). All fistulas were of the vascular type, terminating into either the pulmonary artery (n = 11) or coronary sinus (n = 1). The CAG delineated the characteristics of the fistula (origin, pathway and termination). Multiplicity of the origins and pathways of the fistulous vessels were common in most fistulas (8/12, 67% and 9/12, 75%, respectively). Multiplicity was common among the different fistula components (23/36, 64%). Adenosine pharmacologic stress N-13-ammonia PET-CT revealed normal myocardial perfusion and ejection fraction in all but one patient, who showed a reduced ejection fraction.

CONCLUSION

PET-CT may be helpful for assessing the functional status of congenital CAFs in selected patients regarding clinical decision-making. Studies with a larger patient series are warranted.

Original languageEnglish
Pages (from-to)153-164
Number of pages12
JournalWorld Journal of Cardiology
Volume10
Issue number10
Publication statusPublished - 26-Oct-2018

    Keywords

  • Coronary angiography, Coronary-pulmonary artery fistulas, Adenosine ammonia positron emission tomography computed tomography, Coronary vascular fistulas, Congenital coronary artery fistulas, FRACTIONAL FLOW RESERVE, POSITRON-EMISSION-TOMOGRAPHY, ISCHEMIC-HEART-DISEASE, OF-THE-LITERATURE, ARTERIOVENOUS-FISTULA, FUNCTIONAL ASSESSMENT, VENTRICULAR FUNCTION, COMPUTED-TOMOGRAPHY, MAGNETIC-RESONANCE, PROGNOSTIC VALUE

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