Publication

Incidence of Massive Transfusion and Overall Transfusion Requirements During Lung Transplantation Over a 25-Year Period

Cernak, V., Oude Lansink-Hartgring, A., van den Heuvel, E. R., Verschuuren, E. A. M., van der Bij, W., Scheeren, T. W. L., Engels, G. E., de Geus, A. F., Erasmus, M. E. & de Vries, A. J., Sep-2019, In : Journal of cardiothoracic and vascular anesthesia. 33, 9, p. 2478-2486 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Cernak, V., Oude Lansink-Hartgring, A., van den Heuvel, E. R., Verschuuren, E. A. M., van der Bij, W., Scheeren, T. W. L., ... de Vries, A. J. (2019). Incidence of Massive Transfusion and Overall Transfusion Requirements During Lung Transplantation Over a 25-Year Period. Journal of cardiothoracic and vascular anesthesia, 33(9), 2478-2486. https://doi.org/10.1053/j.jvca.2019.03.060

Author

Cernak, Vladimir ; Oude Lansink-Hartgring, Annemieke ; van den Heuvel, Edwin R ; Verschuuren, Erik A M ; van der Bij, Wim ; Scheeren, Thomas W L ; Engels, Gerwin E ; de Geus, Arian F ; Erasmus, Michiel E ; de Vries, Adrianus J. / Incidence of Massive Transfusion and Overall Transfusion Requirements During Lung Transplantation Over a 25-Year Period. In: Journal of cardiothoracic and vascular anesthesia. 2019 ; Vol. 33, No. 9. pp. 2478-2486.

Harvard

Cernak, V, Oude Lansink-Hartgring, A, van den Heuvel, ER, Verschuuren, EAM, van der Bij, W, Scheeren, TWL, Engels, GE, de Geus, AF, Erasmus, ME & de Vries, AJ 2019, 'Incidence of Massive Transfusion and Overall Transfusion Requirements During Lung Transplantation Over a 25-Year Period', Journal of cardiothoracic and vascular anesthesia, vol. 33, no. 9, pp. 2478-2486. https://doi.org/10.1053/j.jvca.2019.03.060

Standard

Incidence of Massive Transfusion and Overall Transfusion Requirements During Lung Transplantation Over a 25-Year Period. / Cernak, Vladimir; Oude Lansink-Hartgring, Annemieke; van den Heuvel, Edwin R; Verschuuren, Erik A M; van der Bij, Wim; Scheeren, Thomas W L; Engels, Gerwin E; de Geus, Arian F; Erasmus, Michiel E; de Vries, Adrianus J.

In: Journal of cardiothoracic and vascular anesthesia, Vol. 33, No. 9, 09.2019, p. 2478-2486.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Cernak V, Oude Lansink-Hartgring A, van den Heuvel ER, Verschuuren EAM, van der Bij W, Scheeren TWL et al. Incidence of Massive Transfusion and Overall Transfusion Requirements During Lung Transplantation Over a 25-Year Period. Journal of cardiothoracic and vascular anesthesia. 2019 Sep;33(9):2478-2486. https://doi.org/10.1053/j.jvca.2019.03.060


BibTeX

@article{bc11afa40e38413ba8825c1a7f652a5c,
title = "Incidence of Massive Transfusion and Overall Transfusion Requirements During Lung Transplantation Over a 25-Year Period",
abstract = "Objective: To establish the incidence of massive transfusion and overall transfusion requirements during lung transplantation, changes over time, and association with outcome in relation to patient complexity.Design: Retrospective cohort study.Setting: University hospital.Participants: All 514 adult patients who underwent transplantation from 1990 until 2015.Interventions: None.Measurements and Main Results: Patient records and transfusion data, divided into 5-year intervals, were analyzed. The incidence of massive transfusion (>10 units of red blood cells [RBCs] in 24 h) was 27{\%} and did not change over time, whereas the median (interquartile range) transfusion requirement in the whole cohort decreased from 8 (5-12) to 3 (0-10) RBCs (p <0.001). In patients transplanted from the intensive care unit, the incidence of massive transfusion increased over time from 25{\%} to 54{\%} (p = 0.04) and median transfusion requirements from 4.5 (3-8.5) units to 14.5 (5-26) units of RBCs (p = 0.03). Multivariable analysis showed that circulatory support, pulmonary hypertension, re-transplantation, cystic fibrosis, Eisenmenger syndrome, bilateral transplantation, and low body mass index were associated with massive transfusion. Patients with massive transfusion had more primary graft dysfunction grade III at 0, 24, 48, and 72 hours (p <0.001), higher 30-day mortality (13{\%} v 4{\%}; p <0.001), and lower 5-year survival (hazard ratio 3.67 [95{\%} confidence interval 1.72-7.85]; p <0.001).Conclusion: The incidence of massive transfusion did not change over time, whereas transfusion requirements in the whole cohort decreased. In patients transplanted from the intensive care unit, massive transfusion and transfusion requirements increased. Massive transfusion was associated with poor outcome. (C) 2019 Elsevier Inc. All rights reserved.",
keywords = "lung transplantation, massive transfusion, EXTRACORPOREAL MEMBRANE-OXYGENATION, CARDIOPULMONARY BYPASS, BLOOD-TRANSFUSION, MORTALITY, SINGLE",
author = "Vladimir Cernak and {Oude Lansink-Hartgring}, Annemieke and {van den Heuvel}, {Edwin R} and Verschuuren, {Erik A M} and {van der Bij}, Wim and Scheeren, {Thomas W L} and Engels, {Gerwin E} and {de Geus}, {Arian F} and Erasmus, {Michiel E} and {de Vries}, {Adrianus J}",
note = "Copyright {\circledC} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = "9",
doi = "10.1053/j.jvca.2019.03.060",
language = "English",
volume = "33",
pages = "2478--2486",
journal = "Journal of cardiothoracic and vascular anesthesia",
issn = "1053-0770",
publisher = "W B SAUNDERS CO-ELSEVIER INC",
number = "9",

}

RIS

TY - JOUR

T1 - Incidence of Massive Transfusion and Overall Transfusion Requirements During Lung Transplantation Over a 25-Year Period

AU - Cernak, Vladimir

AU - Oude Lansink-Hartgring, Annemieke

AU - van den Heuvel, Edwin R

AU - Verschuuren, Erik A M

AU - van der Bij, Wim

AU - Scheeren, Thomas W L

AU - Engels, Gerwin E

AU - de Geus, Arian F

AU - Erasmus, Michiel E

AU - de Vries, Adrianus J

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/9

Y1 - 2019/9

N2 - Objective: To establish the incidence of massive transfusion and overall transfusion requirements during lung transplantation, changes over time, and association with outcome in relation to patient complexity.Design: Retrospective cohort study.Setting: University hospital.Participants: All 514 adult patients who underwent transplantation from 1990 until 2015.Interventions: None.Measurements and Main Results: Patient records and transfusion data, divided into 5-year intervals, were analyzed. The incidence of massive transfusion (>10 units of red blood cells [RBCs] in 24 h) was 27% and did not change over time, whereas the median (interquartile range) transfusion requirement in the whole cohort decreased from 8 (5-12) to 3 (0-10) RBCs (p <0.001). In patients transplanted from the intensive care unit, the incidence of massive transfusion increased over time from 25% to 54% (p = 0.04) and median transfusion requirements from 4.5 (3-8.5) units to 14.5 (5-26) units of RBCs (p = 0.03). Multivariable analysis showed that circulatory support, pulmonary hypertension, re-transplantation, cystic fibrosis, Eisenmenger syndrome, bilateral transplantation, and low body mass index were associated with massive transfusion. Patients with massive transfusion had more primary graft dysfunction grade III at 0, 24, 48, and 72 hours (p <0.001), higher 30-day mortality (13% v 4%; p <0.001), and lower 5-year survival (hazard ratio 3.67 [95% confidence interval 1.72-7.85]; p <0.001).Conclusion: The incidence of massive transfusion did not change over time, whereas transfusion requirements in the whole cohort decreased. In patients transplanted from the intensive care unit, massive transfusion and transfusion requirements increased. Massive transfusion was associated with poor outcome. (C) 2019 Elsevier Inc. All rights reserved.

AB - Objective: To establish the incidence of massive transfusion and overall transfusion requirements during lung transplantation, changes over time, and association with outcome in relation to patient complexity.Design: Retrospective cohort study.Setting: University hospital.Participants: All 514 adult patients who underwent transplantation from 1990 until 2015.Interventions: None.Measurements and Main Results: Patient records and transfusion data, divided into 5-year intervals, were analyzed. The incidence of massive transfusion (>10 units of red blood cells [RBCs] in 24 h) was 27% and did not change over time, whereas the median (interquartile range) transfusion requirement in the whole cohort decreased from 8 (5-12) to 3 (0-10) RBCs (p <0.001). In patients transplanted from the intensive care unit, the incidence of massive transfusion increased over time from 25% to 54% (p = 0.04) and median transfusion requirements from 4.5 (3-8.5) units to 14.5 (5-26) units of RBCs (p = 0.03). Multivariable analysis showed that circulatory support, pulmonary hypertension, re-transplantation, cystic fibrosis, Eisenmenger syndrome, bilateral transplantation, and low body mass index were associated with massive transfusion. Patients with massive transfusion had more primary graft dysfunction grade III at 0, 24, 48, and 72 hours (p <0.001), higher 30-day mortality (13% v 4%; p <0.001), and lower 5-year survival (hazard ratio 3.67 [95% confidence interval 1.72-7.85]; p <0.001).Conclusion: The incidence of massive transfusion did not change over time, whereas transfusion requirements in the whole cohort decreased. In patients transplanted from the intensive care unit, massive transfusion and transfusion requirements increased. Massive transfusion was associated with poor outcome. (C) 2019 Elsevier Inc. All rights reserved.

KW - lung transplantation

KW - massive transfusion

KW - EXTRACORPOREAL MEMBRANE-OXYGENATION

KW - CARDIOPULMONARY BYPASS

KW - BLOOD-TRANSFUSION

KW - MORTALITY

KW - SINGLE

U2 - 10.1053/j.jvca.2019.03.060

DO - 10.1053/j.jvca.2019.03.060

M3 - Article

C2 - 31147209

VL - 33

SP - 2478

EP - 2486

JO - Journal of cardiothoracic and vascular anesthesia

JF - Journal of cardiothoracic and vascular anesthesia

SN - 1053-0770

IS - 9

ER -

ID: 84385697