Incidence and natural history of challenge-proven cow's milk allergy in European children - EuroPrevall birth cohort

Schoemaker, A. A., Sprikkelman, A. B., Grimshaw, K. E., Roberts, G., Grabenhenrich, L., Rosenfeld, L., Siegert, S., Dubakiene, R., Rudzeviciene, O., Reche, M., Fiandor, A., Papadopoulos, N. G., Malamitsi-Puchner, A., Fiocchi, A., Dahdah, L., Sigurdardottir, S. T., Clausen, M., Stanczyk-Przyluska, A., Zeman, K., Mills, E. N. C., McBride, D., Keil, T. & Beyer, K., Aug-2015, In : Allergy. 70, 8, p. 963-972 10 p.

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  • Incidence and natural history of challenge‐proven cow's milk allergy in European children – EuroPrevall birth cohort

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  • A. A. Schoemaker
  • A. B. Sprikkelman
  • K. E. Grimshaw
  • G. Roberts
  • L. Grabenhenrich
  • L. Rosenfeld
  • S. Siegert
  • R. Dubakiene
  • O. Rudzeviciene
  • M. Reche
  • A. Fiandor
  • N. G. Papadopoulos
  • A. Malamitsi-Puchner
  • A. Fiocchi
  • L. Dahdah
  • S. Th Sigurdardottir
  • M. Clausen
  • A. Stanczyk-Przyluska
  • K. Zeman
  • E. N. C. Mills
  • D. McBride
  • T. Keil
  • K. Beyer

BackgroundCow's milk allergy (CMA) is one of the most commonly reported childhood food problems. Community-based incidence and prevalence estimates vary widely, due to possible misinterpretations of presumed reactions to milk and differences in study design, particularly diagnostic criteria.

MethodsChildren from the EuroPrevall birth cohort in 9 European countries with symptoms possibly related to CMA were invited for clinical evaluation including cows' milk-specific IgE antibodies (IgE), skin prick test (SPT) reactivity and double-blind, placebo-controlled food challenge.

ResultsAcross Europe, 12049 children were enrolled, and 9336 (77.5%) were followed up to 2years of age. CMA was suspected in 358 children and confirmed in 55 resulting in an overall incidence of challenge-proven CMA of 0.54% (95% CI 0.41-0.70). National incidences ranged from 1% (in the Netherlands and UK) to

ConclusionsThis unique pan-European birth cohort study using the gold standard diagnostic procedure for food allergies confirmed challenge-proven CMA in

Original languageEnglish
Pages (from-to)963-972
Number of pages10
Issue number8
Publication statusPublished - Aug-2015
Externally publishedYes


  • birth cohort study, cow's milk allergy, EuroPrevall, food allergy, incidence, IMMUNOGLOBULIN-E LEVELS, FOOD ALLERGY, CLINICAL-COURSE, INFANTS, PREVALENCE, HYPERSENSITIVITY, METAANALYSIS, LIFE

ID: 71332782