Publication

In Vivo Effect of Bradykinin During Ischemia and Reperfusion: Improved Electrical Stability Two Weeks After Myocardial Infarction in the Pig

Tobe, T. J. M., de Langen, C. D. J., Tio, R. A., Bel, K. J., Mook, P. H. & Wesseling, H., Apr-1991, In : Journal of Cardiovascular Pharmacology. 17, 4, p. 600-607 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • T.J.M Tobe
  • C.D.J de Langen
  • R.A Tio
  • K.J. Bel
  • P.H Mook
  • H Wesseling

In this study, the effect of bradykinin or saline infusion during ischemia and reperfusion on electrical stability, 2 weeks after myocardial infarction, was assessed. Acute myocardial infarction was induced in 21 pigs by a transluminal occlusion of the left coronary artery with a catheter balloon, inflated for 45 min. Bradykinin was administered by a 30-min infusion that started after 30 min of coronary occlusion and was continued until 15 min after reperfusion. Although creatine kinase levels in bradykinin-treated animals were significantly lower (p <0.001), 2 week survival was not different between groups. In survivors, the filtered QRS (ventricular deflection) duration (detected using signal-averaged electrocardiography) was significantly prolonged in saline-treated pigs, whereas in bradykinin- treated pigs this prolongation was prevented. The terminal voltage of the QRS complex was significantly lower in saline-treated pigs than in bradykinin-treated pigs. These two parameters signify an improved electrical stability after bradykinin treatment. Refractory periods in saline-treated hearts were longer than in bradykinin-treated hearts (106 +/- 10% vs. 95 +/- 13%, p <0.05). Also, current thresholds in the infarct border zones showed a greater variance in saline-treated hearts (p <0.001), pointing toward more tissue heterogeneity of the infarct border zone. Programmed electrical stimulation showed a trend toward reduced inducibility of sustained ventricular tachycardia in bradykinin-treated hearts.

Therefore, bradykinin improves electrical stability 2 weeks after experimental myocardial infarction.

Original languageEnglish
Pages (from-to)600-607
Number of pages8
JournalJournal of Cardiovascular Pharmacology
Volume17
Issue number4
Publication statusPublished - Apr-1991

    Keywords

  • BRADYKININ, EXPERIMENTAL MYOCARDIAL INFARCTION, ACE INHIBITION, PIG HEART, SIGNAL AVERAGED ELECTROCARDIOGRAPHY, PROGRAMMED ELECTRICAL STIMULATION, SIGNAL-AVERAGED ELECTROCARDIOGRAM, VENTRICULAR-TACHYCARDIA, LATE POTENTIALS, BODY-SURFACE, PROGNOSTIC-SIGNIFICANCE, QRS COMPLEX, STIMULATION, RENIN

ID: 6283810