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In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations

Heeringa, P. & Little, M. A., 28-Feb-2011, In : Arthritis Research and Therapy. 13, 1, 10 p., 204.

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DOI

Anti-neutrophil cytoplasm autoantibody (ANCA)-associated diseases are autoimmune conditions characterized by necrotizing inflammation of small blood vessels. The immunogenesis and etiology of these conditions are unknown, but our knowledge of the immunopathogenesis has increased considerably in recent years. In this review, we discuss the animal models currently used to investigate the mechanisms of vascular injury and to test novel therapies. We outline their advantages and limitations and propose potential directions for future research.

Original languageEnglish
Article number204
Number of pages10
JournalArthritis Research and Therapy
Volume13
Issue number1
Publication statusPublished - 28-Feb-2011

    Keywords

  • ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES, ANTIBODY-MEDIATED GLOMERULONEPHRITIS, IGG GLYCAN HYDROLYSIS, FC-GAMMA RECEPTORS, CRESCENTIC GLOMERULONEPHRITIS, ANTIMYELOPEROXIDASE ANTIBODIES, SYSTEMIC VASCULITIS, NECROTIZING GLOMERULONEPHRITIS, WEGENER AUTOANTIGEN, MERCURIC-CHLORIDE

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