In vitro fertilisation was associated with refractive errors when children reached the age of 11

Kuiper, D., Hendriks, M. W., Veenstra, R., Seggers, J., Haadsma, M. L., Heineman, M. J., Hoek, A. & Hadders-Algra, M., 8-Jul-2019, In : Acta Paediatrica. 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

The primary formation of the eye in the human embryo takes place between weeks three and 10, when the eye expresses oestradiol and progesterone receptors in multiple ocular structures (1). After in vitro fertilisation with controlled ovarian hyperstimulation, serum progesterone and oestradiol concentrations are higher than in natural pregnancies up to week six of embryonic development (2). This could imply that these offspring are vulnerable to altered ophthalmic development. Tornqvist et al studied 24,628 children born by IVF between 1985-2005 and reported that the odds ratio for severe visual impairment was 1.65 compared to the general Swedish population. This article is protected by copyright. All rights reserved.

Original languageEnglish
Number of pages2
JournalActa Paediatrica
Early online date14-Jun-2019
Publication statusPublished - 8-Jul-2019



Download statistics

No data available

ID: 85581347