Publication

In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins

Otzen, M., Krikken, A. M., Ozimek, P. Z., Kurbatova, E., Nagotu, S., Veenhuis, M. & van der Klei, I. J., 2006, In : Fems Yeast Research. 6, 8, p. 1157 - 1166 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Otzen, M., Krikken, A. M., Ozimek, P. Z., Kurbatova, E., Nagotu, S., Veenhuis, M., & van der Klei, I. J. (2006). In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins. Fems Yeast Research, 6(8), 1157 - 1166. https://doi.org/10.1111/j.1567-1364.2006.00102.x

Author

Otzen, Marleen ; Krikken, Arjen M ; Ozimek, Paulina Z ; Kurbatova, Elena ; Nagotu, Shirisha ; Veenhuis, Marten ; van der Klei, Ida J. / In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins. In: Fems Yeast Research. 2006 ; Vol. 6, No. 8. pp. 1157 - 1166.

Harvard

Otzen, M, Krikken, AM, Ozimek, PZ, Kurbatova, E, Nagotu, S, Veenhuis, M & van der Klei, IJ 2006, 'In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins', Fems Yeast Research, vol. 6, no. 8, pp. 1157 - 1166. https://doi.org/10.1111/j.1567-1364.2006.00102.x

Standard

In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins. / Otzen, Marleen; Krikken, Arjen M; Ozimek, Paulina Z; Kurbatova, Elena; Nagotu, Shirisha; Veenhuis, Marten; van der Klei, Ida J.

In: Fems Yeast Research, Vol. 6, No. 8, 2006, p. 1157 - 1166.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Otzen M, Krikken AM, Ozimek PZ, Kurbatova E, Nagotu S, Veenhuis M et al. In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins. Fems Yeast Research. 2006;6(8):1157 - 1166. https://doi.org/10.1111/j.1567-1364.2006.00102.x


BibTeX

@article{0c4e953f038d40939fac7816ef663a76,
title = "In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins",
abstract = "The peroxin Pex19p is important for the formation of functional peroxisomal membranes. Here we show that Hansenula polymorpha Pex19p is also required for peroxisome inheritance. Peroxisome inheritance is partly defective when Pex19p farnesylation is blocked, whereas deletion of PEX19 resulted in a severe defect in partitioning of peroxisomal structures. Time lapse imaging revealed that in newly formed buds, which had not inherited a peroxisome from the mother cell, new peroxisomes are formed that derive from the nuclear envelope/endoplasmic reticulum. This process was impaired upon deletion of EMP24 and ERP3, genes that encode p24 proteins. p24 Proteins are components of coated vesicles that mediate trafficking between the endoplasmic reticulum and Golgi apparatus. In an H. polymorpha wild-type background, deletion of EMP24 and ERP3 resulted in a strong reduction of organelle number in conjunction with an increase in the size of individual peroxisomes. This observation suggests that p24 proteins also play a role in peroxisome development in wild-type H. polymorpha cells.",
keywords = "Hansenula polymorpha, p24 proteins, endoplasmic reticulum, yeast, Pex19p, peroxisome biogenesis",
author = "Marleen Otzen and Krikken, {Arjen M} and Ozimek, {Paulina Z} and Elena Kurbatova and Shirisha Nagotu and Marten Veenhuis and {van der Klei}, {Ida J}",
note = "J EC",
year = "2006",
doi = "10.1111/j.1567-1364.2006.00102.x",
language = "English",
volume = "6",
pages = "1157 -- 1166",
journal = "Fems Yeast Research",
issn = "1567-1356",
number = "8",

}

RIS

TY - JOUR

T1 - In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins

AU - Otzen, Marleen

AU - Krikken, Arjen M

AU - Ozimek, Paulina Z

AU - Kurbatova, Elena

AU - Nagotu, Shirisha

AU - Veenhuis, Marten

AU - van der Klei, Ida J

N1 - J EC

PY - 2006

Y1 - 2006

N2 - The peroxin Pex19p is important for the formation of functional peroxisomal membranes. Here we show that Hansenula polymorpha Pex19p is also required for peroxisome inheritance. Peroxisome inheritance is partly defective when Pex19p farnesylation is blocked, whereas deletion of PEX19 resulted in a severe defect in partitioning of peroxisomal structures. Time lapse imaging revealed that in newly formed buds, which had not inherited a peroxisome from the mother cell, new peroxisomes are formed that derive from the nuclear envelope/endoplasmic reticulum. This process was impaired upon deletion of EMP24 and ERP3, genes that encode p24 proteins. p24 Proteins are components of coated vesicles that mediate trafficking between the endoplasmic reticulum and Golgi apparatus. In an H. polymorpha wild-type background, deletion of EMP24 and ERP3 resulted in a strong reduction of organelle number in conjunction with an increase in the size of individual peroxisomes. This observation suggests that p24 proteins also play a role in peroxisome development in wild-type H. polymorpha cells.

AB - The peroxin Pex19p is important for the formation of functional peroxisomal membranes. Here we show that Hansenula polymorpha Pex19p is also required for peroxisome inheritance. Peroxisome inheritance is partly defective when Pex19p farnesylation is blocked, whereas deletion of PEX19 resulted in a severe defect in partitioning of peroxisomal structures. Time lapse imaging revealed that in newly formed buds, which had not inherited a peroxisome from the mother cell, new peroxisomes are formed that derive from the nuclear envelope/endoplasmic reticulum. This process was impaired upon deletion of EMP24 and ERP3, genes that encode p24 proteins. p24 Proteins are components of coated vesicles that mediate trafficking between the endoplasmic reticulum and Golgi apparatus. In an H. polymorpha wild-type background, deletion of EMP24 and ERP3 resulted in a strong reduction of organelle number in conjunction with an increase in the size of individual peroxisomes. This observation suggests that p24 proteins also play a role in peroxisome development in wild-type H. polymorpha cells.

KW - Hansenula polymorpha

KW - p24 proteins

KW - endoplasmic reticulum

KW - yeast

KW - Pex19p

KW - peroxisome biogenesis

U2 - 10.1111/j.1567-1364.2006.00102.x

DO - 10.1111/j.1567-1364.2006.00102.x

M3 - Article

C2 - 17156013

VL - 6

SP - 1157

EP - 1166

JO - Fems Yeast Research

JF - Fems Yeast Research

SN - 1567-1356

IS - 8

ER -

ID: 1464876