In search of the next super models

Goedel, A., Grote Beverborg, N., Sahara, M. & Chien, K. R., Dec-2019, In : EMBO Molecular Medicine. 11, 12, 3 p., e11502.

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The advent of pluripotent stem cell biology and facile genetic manipulation via CRISPR technology has ushered in a new era of human disease models for drug discovery and development. While these precision "super models" hold great promise for tailoring personalized therapy, their full potential and in vivo validation have remained elusive.

Original languageEnglish
Article numbere11502
Number of pages3
JournalEMBO Molecular Medicine
Issue number12
Publication statusPublished - Dec-2019
Externally publishedYes


  • Actinin, Cardiomyopathy, Hypertrophic, Drug Discovery, Humans, Mutation, Pluripotent Stem Cells

ID: 135796544