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Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry

MR CLEAN Registry Investigators, van Es, A. C. G. M., Yo, L. S. F., Hofmeijer, J., Martens, J. M., van Walderveen, M. A. A., van der Kallen, B. F. W., Jenniskens, S. F. M., Treurniet, K. M., Marqueriny, H. A., Sprengers, M. E. S., Bot, J., Lycklama A Nijeholt, G. J., Lingsma, H. F., Liebeskind, D. S., Boiten, J., Vos, J-A., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van der Lugt, A., van Zwam, W. H., Dippel, D. W. J., van den Wijngaard, I. R. & Majoie, C. B. L. M., Sep-2019, In : Journal of Neurointerventional Surgery. 11, 9, p. 866-873 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

MR CLEAN Registry Investigators, van Es, A. C. G. M., Yo, L. S. F., Hofmeijer, J., Martens, J. M., van Walderveen, M. A. A., ... Majoie, C. B. L. M. (2019). Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry. Journal of Neurointerventional Surgery, 11(9), 866-873. https://doi.org/10.1136/neurintsurg-2018-014619

Author

MR CLEAN Registry Investigators ; van Es, Adriaan C. G. M. ; Yo, Lonneke S. F. ; Hofmeijer, Jeannette ; Martens, Jasper M. ; van Walderveen, Marianne A. A. ; van der Kallen, Bas F. W. ; Jenniskens, Sjoerd F. M. ; Treurniet, Kilian M. ; Marqueriny, Henk A. ; Sprengers, Marieke E. S. ; Bot, Joost ; Lycklama A Nijeholt, Geert J. ; Lingsma, Hester F. ; Liebeskind, David S. ; Boiten, Jelis ; Vos, Jan-Albert ; Roos, Yvo B. W. E. M. ; van Oostenbrugge, Robert J. ; van der Lugt, Aad ; van Zwam, Wim H. ; Dippel, Diederik W. J. ; van den Wijngaard, Ido R. ; Majoie, Charles B. L. M. / Impact of single phase CT angiography collateral status on functional outcome over time : results from the MR CLEAN Registry. In: Journal of Neurointerventional Surgery. 2019 ; Vol. 11, No. 9. pp. 866-873.

Harvard

MR CLEAN Registry Investigators, van Es, ACGM, Yo, LSF, Hofmeijer, J, Martens, JM, van Walderveen, MAA, van der Kallen, BFW, Jenniskens, SFM, Treurniet, KM, Marqueriny, HA, Sprengers, MES, Bot, J, Lycklama A Nijeholt, GJ, Lingsma, HF, Liebeskind, DS, Boiten, J, Vos, J-A, Roos, YBWEM, van Oostenbrugge, RJ, van der Lugt, A, van Zwam, WH, Dippel, DWJ, van den Wijngaard, IR & Majoie, CBLM 2019, 'Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry', Journal of Neurointerventional Surgery, vol. 11, no. 9, pp. 866-873. https://doi.org/10.1136/neurintsurg-2018-014619

Standard

Impact of single phase CT angiography collateral status on functional outcome over time : results from the MR CLEAN Registry. / MR CLEAN Registry Investigators; van Es, Adriaan C. G. M.; Yo, Lonneke S. F.; Hofmeijer, Jeannette; Martens, Jasper M.; van Walderveen, Marianne A. A.; van der Kallen, Bas F. W.; Jenniskens, Sjoerd F. M.; Treurniet, Kilian M.; Marqueriny, Henk A.; Sprengers, Marieke E. S.; Bot, Joost; Lycklama A Nijeholt, Geert J.; Lingsma, Hester F.; Liebeskind, David S.; Boiten, Jelis; Vos, Jan-Albert; Roos, Yvo B. W. E. M.; van Oostenbrugge, Robert J.; van der Lugt, Aad; van Zwam, Wim H.; Dippel, Diederik W. J.; van den Wijngaard, Ido R.; Majoie, Charles B. L. M.

In: Journal of Neurointerventional Surgery, Vol. 11, No. 9, 09.2019, p. 866-873.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

MR CLEAN Registry Investigators, van Es ACGM, Yo LSF, Hofmeijer J, Martens JM, van Walderveen MAA et al. Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry. Journal of Neurointerventional Surgery. 2019 Sep;11(9):866-873. https://doi.org/10.1136/neurintsurg-2018-014619


BibTeX

@article{78d95ba37cf146718e4d0956e427a832,
title = "Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry",
abstract = "Background Collateral status modified the effect of endovascular treatment (EVT) for stroke in several randomized trials. We assessed the association between collaterals and functional outcome in EVT treated patients and investigated if this association is time dependent.Methods We included consecutive patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN) Registry (March 2014-June 2016) with an anterior circulation large vessel occlusion undergoing EVT. Functional outcome was measured on the modified Rankin Scale (mRS) at 90 days. We investigated the association between collaterals and mRS in the MR CLEAN Registry with ordinal logistic regression and if this association was time dependent with an interaction term. Additionally, we determined modification of EVT effect by collaterals compared with MR CLEAN controls, and also investigated if this was time dependent with multiplicative interaction terms.Results 1412 patients were analyzed. Functional independence (mRS score of 0-2) was achieved in 13{\%} of patients with grade 0 collaterals, in 27{\%} with grade 1, in 46{\%} with grade 2, and in 53{\%} with grade 3. Collaterals were significantly associated with mRS (adjusted common OR 1.5 (95{\%} CI 1.4 to 1.7)) and significantly modified EVT benefit (P=0.04). None of the effects were time dependent. Better collaterals corresponded to lower mortality (PConclusion In routine clinical practice, better collateral status is associated with better functional outcome and greater treatment benefit in EVT treated acute ischemic stroke patients, independent of time to treatment. Within the 6 hour time window, a substantial proportion of patients with absent and poor collaterals can still achieve functional independence.",
keywords = "COMPUTED TOMOGRAPHIC ANGIOGRAPHY, LEPTOMENINGEAL COLLATERALS, ENDOVASCULAR TREATMENT, STROKE, REPERFUSION, SCORE, MANAGEMENT, PREDICTOR, THERAPY",
author = "{MR CLEAN Registry Investigators} and Jansen, {Ivo G. H.} and Mulder, {Maxim J. H. L.} and Goldhoorn, {Robert-Jan B.} and Boers, {Anna M. M.} and {van Es}, {Adriaan C. G. M.} and Yo, {Lonneke S. F.} and Jeannette Hofmeijer and Martens, {Jasper M.} and {van Walderveen}, {Marianne A. A.} and {van der Kallen}, {Bas F. W.} and Jenniskens, {Sjoerd F. M.} and Treurniet, {Kilian M.} and Marqueriny, {Henk A.} and Sprengers, {Marieke E. S.} and Schonewille, {Wouter J.} and Joost Bot and {Lycklama A Nijeholt}, {Geert J.} and Lingsma, {Hester F.} and Liebeskind, {David S.} and Jelis Boiten and Jan-Albert Vos and Roos, {Yvo B. W. E. M.} and {van Oostenbrugge}, {Robert J.} and {van der Lugt}, Aad and {van Zwam}, {Wim H.} and Dippel, {Diederik W. J.} and {van den Wijngaard}, {Ido R.} and Majoie, {Charles B. L. M.} and Coutinho, {Jonathan M.} and Wermern, {Marieke J. H.} and Julie Staals and Bob Roozenbeek and Emmer, {Bart J.} and {de Bruijn}, {Sebastiaan F.} and {van Dijk}, {Lukas C.} and {van der Worp}, {H. Bart} and Lo, {Rob H.} and {van Dijk}, {Ewoud J.} and Boogaarts, {Hieronymus D.} and {de Kort}, {Paul L. M.} and Peluso, {Jo J. P.} and {van den Berg}, {Jan S. P.} and {van Hasselt}, {Boudewijn A. A. M.} and Aerden, {Leo A. M.} and Dallinga, {Rene J.} and Maarten Uyttenboogaart and Omid Eshghi and Schreuder, {Tobien H. C. M. L.} and Heijboer, {Roel J. J.} and Groot, {P. F. C.}",
year = "2019",
month = "9",
doi = "10.1136/neurintsurg-2018-014619",
language = "English",
volume = "11",
pages = "866--873",
journal = "Journal of Neurointerventional Surgery",
issn = "1759-8478",
publisher = "BMJ PUBLISHING GROUP",
number = "9",

}

RIS

TY - JOUR

T1 - Impact of single phase CT angiography collateral status on functional outcome over time

T2 - results from the MR CLEAN Registry

AU - MR CLEAN Registry Investigators

AU - Jansen, Ivo G. H.

AU - Mulder, Maxim J. H. L.

AU - Goldhoorn, Robert-Jan B.

AU - Boers, Anna M. M.

AU - van Es, Adriaan C. G. M.

AU - Yo, Lonneke S. F.

AU - Hofmeijer, Jeannette

AU - Martens, Jasper M.

AU - van Walderveen, Marianne A. A.

AU - van der Kallen, Bas F. W.

AU - Jenniskens, Sjoerd F. M.

AU - Treurniet, Kilian M.

AU - Marqueriny, Henk A.

AU - Sprengers, Marieke E. S.

AU - Schonewille, Wouter J.

AU - Bot, Joost

AU - Lycklama A Nijeholt, Geert J.

AU - Lingsma, Hester F.

AU - Liebeskind, David S.

AU - Boiten, Jelis

AU - Vos, Jan-Albert

AU - Roos, Yvo B. W. E. M.

AU - van Oostenbrugge, Robert J.

AU - van der Lugt, Aad

AU - van Zwam, Wim H.

AU - Dippel, Diederik W. J.

AU - van den Wijngaard, Ido R.

AU - Majoie, Charles B. L. M.

AU - Coutinho, Jonathan M.

AU - Wermern, Marieke J. H.

AU - Staals, Julie

AU - Roozenbeek, Bob

AU - Emmer, Bart J.

AU - de Bruijn, Sebastiaan F.

AU - van Dijk, Lukas C.

AU - van der Worp, H. Bart

AU - Lo, Rob H.

AU - van Dijk, Ewoud J.

AU - Boogaarts, Hieronymus D.

AU - de Kort, Paul L. M.

AU - Peluso, Jo J. P.

AU - van den Berg, Jan S. P.

AU - van Hasselt, Boudewijn A. A. M.

AU - Aerden, Leo A. M.

AU - Dallinga, Rene J.

AU - Uyttenboogaart, Maarten

AU - Eshghi, Omid

AU - Schreuder, Tobien H. C. M. L.

AU - Heijboer, Roel J. J.

AU - Groot, P. F. C.

PY - 2019/9

Y1 - 2019/9

N2 - Background Collateral status modified the effect of endovascular treatment (EVT) for stroke in several randomized trials. We assessed the association between collaterals and functional outcome in EVT treated patients and investigated if this association is time dependent.Methods We included consecutive patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN) Registry (March 2014-June 2016) with an anterior circulation large vessel occlusion undergoing EVT. Functional outcome was measured on the modified Rankin Scale (mRS) at 90 days. We investigated the association between collaterals and mRS in the MR CLEAN Registry with ordinal logistic regression and if this association was time dependent with an interaction term. Additionally, we determined modification of EVT effect by collaterals compared with MR CLEAN controls, and also investigated if this was time dependent with multiplicative interaction terms.Results 1412 patients were analyzed. Functional independence (mRS score of 0-2) was achieved in 13% of patients with grade 0 collaterals, in 27% with grade 1, in 46% with grade 2, and in 53% with grade 3. Collaterals were significantly associated with mRS (adjusted common OR 1.5 (95% CI 1.4 to 1.7)) and significantly modified EVT benefit (P=0.04). None of the effects were time dependent. Better collaterals corresponded to lower mortality (PConclusion In routine clinical practice, better collateral status is associated with better functional outcome and greater treatment benefit in EVT treated acute ischemic stroke patients, independent of time to treatment. Within the 6 hour time window, a substantial proportion of patients with absent and poor collaterals can still achieve functional independence.

AB - Background Collateral status modified the effect of endovascular treatment (EVT) for stroke in several randomized trials. We assessed the association between collaterals and functional outcome in EVT treated patients and investigated if this association is time dependent.Methods We included consecutive patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN) Registry (March 2014-June 2016) with an anterior circulation large vessel occlusion undergoing EVT. Functional outcome was measured on the modified Rankin Scale (mRS) at 90 days. We investigated the association between collaterals and mRS in the MR CLEAN Registry with ordinal logistic regression and if this association was time dependent with an interaction term. Additionally, we determined modification of EVT effect by collaterals compared with MR CLEAN controls, and also investigated if this was time dependent with multiplicative interaction terms.Results 1412 patients were analyzed. Functional independence (mRS score of 0-2) was achieved in 13% of patients with grade 0 collaterals, in 27% with grade 1, in 46% with grade 2, and in 53% with grade 3. Collaterals were significantly associated with mRS (adjusted common OR 1.5 (95% CI 1.4 to 1.7)) and significantly modified EVT benefit (P=0.04). None of the effects were time dependent. Better collaterals corresponded to lower mortality (PConclusion In routine clinical practice, better collateral status is associated with better functional outcome and greater treatment benefit in EVT treated acute ischemic stroke patients, independent of time to treatment. Within the 6 hour time window, a substantial proportion of patients with absent and poor collaterals can still achieve functional independence.

KW - COMPUTED TOMOGRAPHIC ANGIOGRAPHY

KW - LEPTOMENINGEAL COLLATERALS

KW - ENDOVASCULAR TREATMENT

KW - STROKE

KW - REPERFUSION

KW - SCORE

KW - MANAGEMENT

KW - PREDICTOR

KW - THERAPY

U2 - 10.1136/neurintsurg-2018-014619

DO - 10.1136/neurintsurg-2018-014619

M3 - Article

VL - 11

SP - 866

EP - 873

JO - Journal of Neurointerventional Surgery

JF - Journal of Neurointerventional Surgery

SN - 1759-8478

IS - 9

ER -

ID: 101940216