Impact of secondary cardiovascular events on health status

van Stel, H. F., Busschbach, J. J. V., Hunink, M. G. M. & Buskens, E., 2012, In : Value in Health. 15, 1, p. 175-182 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Henk F. van Stel
  • Jan J. V. Busschbach
  • M. G. Myriam Hunink
  • Erik Buskens

Objectives: Estimates regarding the impact of secondary cardiovascular events on health status in patients treated for cardiovascular disease are scarce and of limited accuracy. Methods: We obtained individual patient data on health status (EuroQol five-dimensional questionnaire) and secondary cardiovascular events (death, myocardial infarction, cerebrovascular accidents, amputation, extracranial bleeding, and reinterventions) observed during 12 to 36 months of follow-up. Data originated from five completed clinical trials on revascularization in coronary heart disease (n = 2593) or peripheral arterial disease (PAD; n = 1379). We used linear mixed-effects modeling to estimate the acute impact of the initial secondary event and the health status before and after the event. Results: A total of 1595 patients had at least one secondary event. Loss of health status just before the event ranged from 0.36 utility score for amputation in women with PAD to zero for cerebrovascular accident in men with PAD. In patients with coronary heart disease, pre-event health status loss ranged from 0.34 for extracranial bleeding in women to 0.10 for myocardial infarction in women. The acute impact of secondary events ranged from minor deterioration for cerebrovascular accident (-0.03) to improvement after all other events, ranging from +0.01 for occlusion to +0.22 for amputation. Women had significantly lower pre-event scores than did men: -0.04 to -0.10 in coronary heart disease and -0.04 to -0.27 in PAD. Older patients had mostly large but insignificantly lower pre-event scores than did younger patients (range +0.04 to -0.67). Conclusions: Secondary events after revascularization in patients with cardiovascular disease are associated with health status loss before the event, while acute impact of the events was mostly small.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalValue in Health
Issue number1
Publication statusPublished - 2012


  • cardiovascular events, coronary heart diseases, health status, individual patient data, peripheral vascular disease, outcome assessment (health care), technology assessment, QUALITY-OF-LIFE, BYPASS-GRAFTING SURGERY, ARTERY OCCLUSIVE DISEASE, COST-EFFECTIVENESS, STENT PLACEMENT, ON-PUMP, ANGIOPLASTY, STROKE, TRIAL, HEART

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