Impact of medical microbiology: A clinical and financial analysis

Dik, J-W., 2016, [Groningen]: Rijksuniversiteit Groningen. 206 p.

Research output: ThesisThesis fully internal (DIV)Academic

Copy link to clipboard


  • Title and contents

    Final publisher's version, 425 KB, PDF document

  • Chapter 1

    Final publisher's version, 809 KB, PDF document

  • Chapter 2

    Final publisher's version, 825 KB, PDF document

  • Chapter 3

    Final publisher's version, 883 KB, PDF document

  • Chapter 4

    Final publisher's version, 724 KB, PDF document

  • Chapter 5

    Final publisher's version, 944 KB, PDF document

  • Chapter 6

    Final publisher's version, 910 KB, PDF document

  • Chapter 7

    Final publisher's version, 963 KB, PDF document

  • Chapter 8

    Final publisher's version, 721 KB, PDF document

  • Chapter 9

    Final publisher's version, 1 MB, PDF document

  • Chapter 10

    Final publisher's version, 715 KB, PDF document

  • Chapter 11

    Final publisher's version, 737 KB, PDF document

  • Appendices

    Final publisher's version, 926 KB, PDF document

  • Complete thesis

    Final publisher's version, 3 MB, PDF document

  • Propositions

    Final publisher's version, 699 KB, PDF document

To be able to provide cost-effective healthcare, it is important to evaluate the impact of interventions. This thesis looked at interventions performed by the Department of Medical Microbiology at the University Medical Center Groningen. This department plays an important role in infection management and controlling antimicrobial resistance. We developed an integrative infection management model: the Antimicrobial, Infection Prevention and Diagnostic (AID) Stewardship Program; and argue that all three areas are essential for good quality of care. For each area, interventions were evaluated. The implemented intervention for Antimicrobial Stewardship (day-2 bundle) reduced length of stay for a subset of patients, with a positive return on investment. Regarding Infection Prevention Stewardship, costs of outbreaks with (resistant) microorganisms were substantial (€519 per patient per day). Furthermore, increasingly more patients enter the hospital carrying these bacteria, increasing outbreak risks. However, number of outbreak patients remained stable, suggesting a positive impact of increased infection prevention measures. Also here, predicted benefits outweighed costs. Finally, effects of taking blood cultures were evaluated as part of Diagnostic Stewardship. Blood cultures were performed for just 48% of the evaluated patients receiving antibiotics intravenously. We showed that taking blood cultures was associated with a shorter length of stay of these patients. In conclusion, good infection management has highly positive effects on patients and finances. To stimulate appropriate infection management, to create financial incentives and provide more clarity in internal budgeting, we argue for implementation of an innovative infection prevention insurance system, and process-oriented, quality-driven cost-effectiveness analyses to guide decisions.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Friedrich, Alex, Supervisor
  • Sinha, Bhanu, Supervisor
  • Postma, Maarten, Supervisor
  • Hendrix, M. G. R., Co-supervisor, External person
  • Degener, John, Assessment committee
  • Kluytmans, J. A. J. W., Assessment committee, External person
  • Voss, Andreas, Assessment committee, External person
Award date7-Nov-2016
Place of Publication[Groningen]
Print ISBNs9789036792165
Electronic ISBNs9789036792103
Publication statusPublished - 2016

Download statistics

No data available

ID: 36406764