Impact of fasting on F-18-fluorocholine gastrointestinal uptake and detection of lymph node metastases in patients with prostate cancer

Wondergem, M., van der Zant, F. M., Knol, R. J. J., Pruim, J. & de Jong, I. J., 6-Jan-2016, In : EJNMMI Research. 6, 2, p. 1-5 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background: F-18-fluorocholine PET/CT is used to detect lymph node metastases in prostate cancer patients. Physiological F-18-fluorocholine in the gastrointestinal tract, especially in the intestines, may interfere with the detection of malignant lymph nodes. Fasting is frequently proposed in literature; however, scientific support is lacking. This study aims to determine the impact of fasting on F-18-fluorocholine uptake in the gastrointestinal tract.

Methods: Eighty patients were studied, 40 fasted for at least 6 h prior to F-18-fluorocholine administration while the other 40 did not fast. F-18-fluorocholine uptake pattern and intensity were evaluated in the intestine near the abdominal aorta and four regions near the iliac arteries. F-18-fluorocholine intensity was also measured in the liver, pancreas, stomach and spleen.

Findings: No statistically significant differences were found in F-18-fluorocholine uptake in the gastrointestinal tract between the fasting and non-fasting group.

Conclusions: Fasting for 6 h has no effect on F-18-fluorocholine uptake in the gastrointestinal tract. Therefore, no effects on the detection of malignant lymph nodes are expected, and fasting is not recommended in our opinion.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalEJNMMI Research
Issue number2
Publication statusPublished - 6-Jan-2016


  • F-18-fluorocholine, PET/CT, Prostate cancer, Urology, Patient preparations

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