Publication

Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

Vich Vila, A., Collij, V., Sanna, S., Sinha, T., Imhann, F., Bourgonje, A. R., Mujagic, Z., Jonkers, D. M. A. E., Masclee, A. A. M., Fu, J., Kurilshikov, A., Wijmenga, C., Zhernakova, A. & Weersma, R. K., 17-Jan-2020, In : Nature Communications. 11, 1, 11 p., 362.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Vich Vila, A., Collij, V., Sanna, S., Sinha, T., Imhann, F., Bourgonje, A. R., Mujagic, Z., Jonkers, D. M. A. E., Masclee, A. A. M., Fu, J., Kurilshikov, A., Wijmenga, C., Zhernakova, A., & Weersma, R. K. (2020). Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. Nature Communications, 11(1), [362]. https://doi.org/10.1038/s41467-019-14177-z

Author

Vich Vila, Arnau ; Collij, Valerie ; Sanna, Serena ; Sinha, Trishla ; Imhann, Floris ; Bourgonje, Arno R ; Mujagic, Zlatan ; Jonkers, Daisy M A E ; Masclee, Ad A M ; Fu, Jingyuan ; Kurilshikov, Alexander ; Wijmenga, Cisca ; Zhernakova, Alexandra ; Weersma, Rinse K. / Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Harvard

Vich Vila, A, Collij, V, Sanna, S, Sinha, T, Imhann, F, Bourgonje, AR, Mujagic, Z, Jonkers, DMAE, Masclee, AAM, Fu, J, Kurilshikov, A, Wijmenga, C, Zhernakova, A & Weersma, RK 2020, 'Impact of commonly used drugs on the composition and metabolic function of the gut microbiota', Nature Communications, vol. 11, no. 1, 362. https://doi.org/10.1038/s41467-019-14177-z

Standard

Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. / Vich Vila, Arnau; Collij, Valerie; Sanna, Serena; Sinha, Trishla; Imhann, Floris; Bourgonje, Arno R; Mujagic, Zlatan; Jonkers, Daisy M A E; Masclee, Ad A M; Fu, Jingyuan; Kurilshikov, Alexander; Wijmenga, Cisca; Zhernakova, Alexandra; Weersma, Rinse K.

In: Nature Communications, Vol. 11, No. 1, 362, 17.01.2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Vich Vila A, Collij V, Sanna S, Sinha T, Imhann F, Bourgonje AR et al. Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. Nature Communications. 2020 Jan 17;11(1). 362. https://doi.org/10.1038/s41467-019-14177-z


BibTeX

@article{b1e0d4bab46849cdbf983e2e62f0bcb5,
title = "Impact of commonly used drugs on the composition and metabolic function of the gut microbiota",
abstract = "The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. However, drug–microbe interactions are still understudied in the clinical context, where polypharmacy and comorbidities co-occur. Here, we report relations between commonly used drugs and the gut microbiome. We performed metagenomics sequencing of faecal samples from a population cohort and two gastrointestinal disease cohorts. Differences between users and non-users were analysed per cohort, followed by a meta-analysis. While 19 of 41 drugs are found to be associated with microbial features, when controlling for the use of multiple medications, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest associations with the microbiome. We here provide evidence for extensive changes in taxonomy, metabolic potential and resistome in relation to commonly used drugs. This paves the way for future studies and has implications for current microbiome studies by demonstrating the need to correct for multiple drug use.",
keywords = "PROTON PUMP INHIBITORS, IRRITABLE-BOWEL-SYNDROME, IDENTIFICATION, RESISTANCE, ARTHRITIS",
author = "{Vich Vila}, Arnau and Valerie Collij and Serena Sanna and Trishla Sinha and Floris Imhann and Bourgonje, {Arno R} and Zlatan Mujagic and Jonkers, {Daisy M A E} and Masclee, {Ad A M} and Jingyuan Fu and Alexander Kurilshikov and Cisca Wijmenga and Alexandra Zhernakova and Weersma, {Rinse K}",
year = "2020",
month = jan,
day = "17",
doi = "10.1038/s41467-019-14177-z",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

AU - Vich Vila, Arnau

AU - Collij, Valerie

AU - Sanna, Serena

AU - Sinha, Trishla

AU - Imhann, Floris

AU - Bourgonje, Arno R

AU - Mujagic, Zlatan

AU - Jonkers, Daisy M A E

AU - Masclee, Ad A M

AU - Fu, Jingyuan

AU - Kurilshikov, Alexander

AU - Wijmenga, Cisca

AU - Zhernakova, Alexandra

AU - Weersma, Rinse K

PY - 2020/1/17

Y1 - 2020/1/17

N2 - The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. However, drug–microbe interactions are still understudied in the clinical context, where polypharmacy and comorbidities co-occur. Here, we report relations between commonly used drugs and the gut microbiome. We performed metagenomics sequencing of faecal samples from a population cohort and two gastrointestinal disease cohorts. Differences between users and non-users were analysed per cohort, followed by a meta-analysis. While 19 of 41 drugs are found to be associated with microbial features, when controlling for the use of multiple medications, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest associations with the microbiome. We here provide evidence for extensive changes in taxonomy, metabolic potential and resistome in relation to commonly used drugs. This paves the way for future studies and has implications for current microbiome studies by demonstrating the need to correct for multiple drug use.

AB - The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. However, drug–microbe interactions are still understudied in the clinical context, where polypharmacy and comorbidities co-occur. Here, we report relations between commonly used drugs and the gut microbiome. We performed metagenomics sequencing of faecal samples from a population cohort and two gastrointestinal disease cohorts. Differences between users and non-users were analysed per cohort, followed by a meta-analysis. While 19 of 41 drugs are found to be associated with microbial features, when controlling for the use of multiple medications, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest associations with the microbiome. We here provide evidence for extensive changes in taxonomy, metabolic potential and resistome in relation to commonly used drugs. This paves the way for future studies and has implications for current microbiome studies by demonstrating the need to correct for multiple drug use.

KW - PROTON PUMP INHIBITORS

KW - IRRITABLE-BOWEL-SYNDROME

KW - IDENTIFICATION

KW - RESISTANCE

KW - ARTHRITIS

U2 - 10.1038/s41467-019-14177-z

DO - 10.1038/s41467-019-14177-z

M3 - Article

C2 - 31953381

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 362

ER -

ID: 112912770