Publication

Immunomodulatory Effects of Macrolide Antibiotics - Part 1: Biological Mechanisms

Altenburg, J., de Graaff, C. S., van der Werf, T. S. & Boersma, W. G., 2011, In : Respiration. 81, 1, p. 67-74 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Macrolide antibiotics are well known for their antibacterial and anti-inflammatory properties. This article provides an overview of the biological mechanisms through which macrolides exert this 'double effect'. Their antibacterial effect consists of the inhibition of bacterial protein synthesis, impaired bacterial biofilm synthesis, and the attenuation of other bacterial virulence factors. Apart from these direct antimicrobial effects, macrolides are known for their modulating effect on many components of the human immune system. By influencing the production of cytokines, they have a dampening effect on the proinflammatory response. Furthermore, the majority of cells involved in the immune response are, in one way or another, influenced when macrolide antibiotics are administered. Having such an obvious effect on the various aspects of the immune system, macrolides seem to be exceptionally suited for the treatment of chronic inflammatory diseases. Copyright (C) 2010 S. Karger AG, Basel

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalRespiration
Volume81
Issue number1
Publication statusPublished - 2011

    Keywords

  • Diffuse panbronchiolitis, Macrolides, Quorum sensing, BRONCHIAL EPITHELIAL-CELLS, BRONCHOALVEOLAR LAVAGE FLUID, LOW-DOSE ERYTHROMYCIN, HUMAN POLYMORPHONUCLEAR LEUKOCYTES, NEUTROPHILIC AIRWAY INFLAMMATION, CHEMICALLY-MODIFIED TETRACYCLINE, OBSTRUCTIVE PULMONARY-DISEASE, LONG-TERM THERAPY, PSEUDOMONAS-AERUGINOSA, IN-VITRO

ID: 5287888