Immunofluorescence of Autoimmune Bullous DiseasesDiercks, G. F., Pas, H. H. & Jonkman, M. F. Jun-2017 (Accepted/In press) In : Surgical pathology clinics. 10, 2, p. 505-512 8 p.
Research output: Scientific - peer-review › Review article
Autoimmmune bullous diseases of skin and mucosa are uncommon, disabling, and potentially lethal diseases. For a quick and reliable diagnosis immunofluorescence is essential. This article describes two variants of immunofluorescence. The direct method uses a skin or mucosal biopsy of the patient to detect in vivo bound antibodies. Indirect immunofluorescence uses patient's serum and a substrate to visualize circulating autoantibodies. These two methods supplemented with advanced techniques allow reliable classification of autoimmune bullous diseases; not only the main entities pemphigus and pemphigoid, but also subclasses within these groups. This is important because prognosis and therapy vary among different variants of autoimmune bullous diseases.
|Number of pages||8|
|Journal||Surgical pathology clinics|
|State||Accepted/In press - Jun-2017|
- Journal Article, Review