Immunofluorescence of Autoimmune Bullous Diseases

Diercks, G. F., Pas, H. H. & Jonkman, M. F. Jun-2017 (Accepted/In press) In : Surgical pathology clinics. 10, 2, p. 505-512 8 p.

Research output: Scientific - peer-reviewReview article

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  • Immunofluorescence of Autoimmune Bullous Diseases

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Autoimmmune bullous diseases of skin and mucosa are uncommon, disabling, and potentially lethal diseases. For a quick and reliable diagnosis immunofluorescence is essential. This article describes two variants of immunofluorescence. The direct method uses a skin or mucosal biopsy of the patient to detect in vivo bound antibodies. Indirect immunofluorescence uses patient's serum and a substrate to visualize circulating autoantibodies. These two methods supplemented with advanced techniques allow reliable classification of autoimmune bullous diseases; not only the main entities pemphigus and pemphigoid, but also subclasses within these groups. This is important because prognosis and therapy vary among different variants of autoimmune bullous diseases.

Original languageEnglish
Pages (from-to)505-512
Number of pages8
JournalSurgical pathology clinics
Issue number2
StateAccepted/In press - Jun-2017


  • Journal Article, Review

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