Publication

Immune regulatory mechanisms in ANCA-associated vasculitides

Lepse, N., Abdulahad, W. H., Kallenberg, C. G. M. & Heeringa, P., Dec-2011, In : Autoimmunity reviews. 11, 2, p. 77-83 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

A group of primary vasculitides is associated with the presence of anti-neutrophil cytoplasmic autoantibodies (ANCA). In these diseases, the contribution of ANCA to disease pathogenesis has been studied extensively. Also, in patients with ANCA-associated vasculitides, the T lymphocyte compartment is dysregulated, as aberrant distribution and function of T cell subsets has been shown. In this review we will discuss the putative role of T lymphocytes in inflammation and granuloma formation, as well as the involvement of B cell compartments in the pathophysiology of ANCA-associated vasculitis.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalAutoimmunity reviews
Volume11
Issue number2
Publication statusPublished - Dec-2011

    Keywords

  • Vasculitides, ANCA, T cells, B cells, MEMORY T-CELLS, ACTIVATION IN-VITRO, WEGENERS-GRANULOMATOSIS, DISEASE-ACTIVITY, B-CELLS, TH17 CELLS, MICROSCOPIC POLYANGIITIS, CYTOPLASMIC AUTOANTIBODIES, NATURAL AUTOANTIBODIES, SYSTEMIC VASCULITIS

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