Publication

Immune activation modulates hematopoiesis through interactions between CD27 and CD70

Nolte, MA., Arens, R., van Os, R., van Oosterwijk, M., Hooibrink, B., van Lier, RAW. & van Oers, MHJ., Apr-2005, In : Nature Immunology. 6, 4, p. 412-418 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • MA Nolte
  • R Arens
  • R van Os
  • M van Oosterwijk
  • B Hooibrink
  • RAW van Lier
  • MHJ van Oers

The differentiation of hematopoietic stem cells into mature blood cell lineages is tightly regulated. Here we report that CD27, which is expressed on stem and early progenitor cells in bone marrow, can be important in this process. Deletion of CD27 increased the myeloid colony - forming potential of stem and early progenitor cells and enhanced B lymphoid reconstitutive capacity in competitive transplantation experiments. Conversely, stimulation of CD27(+) progenitor cells with CD70, the unique ligand for CD27, inhibited colony-forming potential in vitro and lymphocyte outgrowth in vivo. As CD70 is expressed only on activated immune cells, we suggest that CD27 triggering on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation.

Original languageEnglish
Pages (from-to)412-418
Number of pages7
JournalNature Immunology
Volume6
Issue number4
Publication statusPublished - Apr-2005

    Keywords

  • NECROSIS-FACTOR RECEPTOR, MEMORY B-CELLS, N-TERMINAL KINASE, BONE-MARROW, STEM-CELLS, T-CELLS, CD27/CD70 INTERACTION, PLASMA-CELLS, PROGENITOR CELLS, SELF-RENEWAL

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