Image Quality and Activity Optimization in Oncologic F-18-FDG PET Using the Digital Biograph Vision PET/CT Systemvan Sluis, J., Boellaard, R., Dierckx, R. A., Stormezand, G., Glaudemans, A. W. J. M. & Noordzij, W., 1-May-2020, In : Journal of Nuclear Medicine. 61, 5, p. 764-771 8 p.
Research output: Contribution to journal › Article › Academic › peer-review
The first Biograph Vision PET/CT system (Siemens Healthineers) was installed at the University Medical Center Groningen. Improved performance of this system could allow for a reduction in activity administration or scan duration. This study evaluated the effects of reduced scan duration in oncologic F-18-FDG PET imaging on quantitative and subjective imaging parameters and its influence on clinical image interpretation. Methods: Patients referred for a clinical PET/CT scan were enrolled in this study, received a weight-based F-18-FDG injected activity, and underwent list-mode PET acquisition at 180 s per bed position (s/bp). Acquired PET data were reconstructed using the vendor-recommended clinical reconstruction protocol (hereafter referred to as "clinical"), using the clinical protocol with additional 2-mm gaussian filtering (hereafter referred to as "clinical+G2"), and in conformance with European Association of Nuclear Medicine Research Ltd. (EARL) specifications using different scan durations per bed position (180, 120, 60, 30, and 10 s). Reconstructed images were quantitatively assessed for comparison of SUVs and noise. In addition, clinically reconstructed images were qualitatively evaluated by 3 nuclear medicine physicians. Results: In total, 30 oncologic patients (22 men, 8 women; age: 48-88 y [range], 67 +/- 9.6 y [mean SD]) received a single weight-based (3 MBq/kg) F-18-FDG injected activity (weight: 45-123 kg [range], 81 +/- 15 kg [mean SD]; activity: 135-380 MBq [range], 241 +/- 47.3 MBq [mean SD]). Significant differences in lesion SUVmax were found between the 180-s/bp images and the 30- and 10-s/bp images reconstructed using the clinical protocols, whereas no differences were found in lesion SUVpeak. EARL-compliant images did not show differences in lesion SUVmax or SUVpeak between scan durations. Quantitative parameters showed minimal deviation (-5%) in the 60-s/bp images. Therefore, further subjective image quality assessment was conducted using the 60-s/bp images. Qualitative assessment revealed the influence of personal preference on physicians' willingness to adopt the 60-s/bp images in clinical practice. Although quantitative PET parameters differed minimally, an increase in noise was observed. Conclusion: With the Biograph Vision PET/CT system for oncologic F-18-FDG imaging, scan duration or activity administration could be reduced by a factor of 3 or more with the use of the clinical+G2 or the EARL-compliant reconstruction protocol.
|Number of pages||8|
|Journal||Journal of Nuclear Medicine|
|Early online date||18-Oct-2019|
|Publication status||Published - 1-May-2020|
- image quality, activity optimization, scan duration, silicon photomultiplier based detector, PET/CT, INITIAL-EXPERIENCE, QUANTIFICATION, TIME