Image quality and activity optimization in oncological 18F-FDG PET using the digital Biograph Vision PET/CT

van Sluis, J., Boellaard, R., Dierckx, R. A., Stormezand, G., Glaudemans, A. W. J. M. & Noordzij, W., 18-Oct-2019, In : Journal of Nuclear Medicine. 31 p.

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  • Image quality and activity optimization in oncological 18F-FDG PET using the digital Biograph Vision PET/CT

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The first Siemens Biograph Vision PET/CT system (Siemens Healthineers, Knoxville, USA) was installed at the University Medical Center Groningen. Improved performance of this system could allow for a reduction in activity administration and/or scan duration. This study evaluates the effects of reduced scan duration in oncological 18F-FDG PET imaging on quantitative and subjective imaging parameters and its influence on clinical image reading. Methods: Patients referred for a clinical PET/CT scan were enrolled in this study, received a weight-based 18F-FDG injected activity, and underwent a 180 seconds per bed position (s/bp) list-mode PET acquisition. Acquired PET data were reconstructed using the clinically vendor recommended reconstruction protocol (hereinafter referred to as Clinical), using the Clinical protocol with additional 2 mm Gaussian filtering (hereinafter referred to as Clinical+G2) as well as conform European Association of Nuclear Medicine Research Ltd (EARL) specifications using different scan durations per bed position (180, 120, 60, 30, and 10 s). Reconstructed images were quantitatively assessed for comparison of standardized uptake values (SUVs) and noise. In addition, Clinically reconstructed images were qualitatively evaluated by three nuclear medicine physicians. Results: In total, 30 oncological patients (22 men, 8 women; age 48-88, mean ± SD 67 ± 9.6 years) received a single weight-based (3 MBq/kg) 18F-FDG injected activity (weight 45-123 kg, mean ± SD 81 ± 15; activity 135-380 MBq, mean ± SD 241 ± 46.5). Significant differences in lesion SUVmax were found between the 180 s/bp images and the 30 and 10 s/bp images reconstructed using the Clinical protocols, whereas no differences were found in lesion SUVpeak. EARL compliant images did not show differences in lesion SUVmax or SUVpeak between scan durations. Quantitative parameters showed minimal deviation (~5%) in the 60 s/bp images. Further subjective image quality assessment was therefore conducted using the 60 s/bp images. Qualitative assessment revealed the influence of personal preference on physicians' willingness to adopt the 60 s/bp images in clinical practice. Although quantitative PET parameters differed minimally, an increase in noise was observed. Conclusion: Using the Biograph Vision PET/CT for oncological 18F-FDG imaging, scan duration and/or activity administration could be reduced by a factor of three or more when using the Clinical+G2 or the EARL compliant reconstruction protocol, respectively.

Original languageEnglish
Number of pages31
JournalJournal of Nuclear Medicine
Publication statusE-pub ahead of print - 18-Oct-2019

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