Publication

IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels

Arguinano, A. A., Naderi, E., Ndiaye, N. C., Stathopoulou, M., Dade, S., Alizadeh, B. & Visvikis-Siesit, S., Oct-2017, In : GENES AND IMMUNITY. 18, 3, p. 163-169 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Arguinano, A. A., Naderi, E., Ndiaye, N. C., Stathopoulou, M., Dade, S., Alizadeh, B., & Visvikis-Siesit, S. (2017). IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels. GENES AND IMMUNITY, 18(3), 163-169. https://doi.org/10.1038/gene.2017.16

Author

Arguinano, A. A. ; Naderi, E. ; Ndiaye, N. C. ; Stathopoulou, M. ; Dade, S. ; Alizadeh, B. ; Visvikis-Siesit, S. / IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels. In: GENES AND IMMUNITY. 2017 ; Vol. 18, No. 3. pp. 163-169.

Harvard

Arguinano, AA, Naderi, E, Ndiaye, NC, Stathopoulou, M, Dade, S, Alizadeh, B & Visvikis-Siesit, S 2017, 'IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels', GENES AND IMMUNITY, vol. 18, no. 3, pp. 163-169. https://doi.org/10.1038/gene.2017.16

Standard

IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels. / Arguinano, A. A.; Naderi, E.; Ndiaye, N. C.; Stathopoulou, M.; Dade, S.; Alizadeh, B.; Visvikis-Siesit, S.

In: GENES AND IMMUNITY, Vol. 18, No. 3, 10.2017, p. 163-169.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Arguinano AA, Naderi E, Ndiaye NC, Stathopoulou M, Dade S, Alizadeh B et al. IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels. GENES AND IMMUNITY. 2017 Oct;18(3):163-169. https://doi.org/10.1038/gene.2017.16


BibTeX

@article{dce2b99e12de4620bb73711cb7677d09,
title = "IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels",
abstract = "Interleukin 6 receptor (IL-6R), mediating IL-6's biological functions, plays an important role in different diseases such as diabetes, obesity and cardio-vascular diseases. In this study, we investigated the effects of two single nucleotide polymorphisms (SNPs), within the IL-6R loci, previously associated with C-reactive protein (CRP) and coronary heart diseases risk, and with controversial effects on lipids traits: SNP rs4845625 and SNP rs4537545. The results showed that both investigated SNPs were antagonistically related with CRP levels; the minor rs4845625*T allele was associated with increased CRP levels (P-value = 0.011), while the minor rs4537545* T allele was associated with decreased CRP levels (P-value = 0.009). Interestingly, the minor rs4845625* T allele was significantly associated with higher low-density lipoprotein cholesterol (LDL-C) and ApoB levels (P = 0.007 and P = 0.009 respectively). Haplotype analysis showed that the TC haplotype, having the minor rs4845625* T allele, was related simultaneously with increased levels of CRP, LDL-C and ApoB levels, thus could be considered as a risk factor. Our investigation detects for the first time an independent effect of rs4845625 on LDL-C and ApoB traits, explaining an important range of those traits variability (3.49 and 5.57{\%} respectively). Our findings might be of high clinical significance in pharmacogenomics studies of tocilizumab for which IL-6R is target.",
keywords = "INTERLEUKIN-6 RECEPTOR GENE, DENSITY-LIPOPROTEIN CHOLESTEROL, CORONARY-HEART-DISEASE, C-REACTIVE PROTEIN, METABOLIC SYNDROME, ASSOCIATION ANALYSES, VARIANTS, INFLAMMATION, POLYMORPHISM, TOCILIZUMAB",
author = "Arguinano, {A. A.} and E. Naderi and Ndiaye, {N. C.} and M. Stathopoulou and S. Dade and B. Alizadeh and S. Visvikis-Siesit",
year = "2017",
month = "10",
doi = "10.1038/gene.2017.16",
language = "English",
volume = "18",
pages = "163--169",
journal = "GENES AND IMMUNITY",
issn = "1466-4879",
publisher = "Nature Publishing Group",
number = "3",

}

RIS

TY - JOUR

T1 - IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels

AU - Arguinano, A. A.

AU - Naderi, E.

AU - Ndiaye, N. C.

AU - Stathopoulou, M.

AU - Dade, S.

AU - Alizadeh, B.

AU - Visvikis-Siesit, S.

PY - 2017/10

Y1 - 2017/10

N2 - Interleukin 6 receptor (IL-6R), mediating IL-6's biological functions, plays an important role in different diseases such as diabetes, obesity and cardio-vascular diseases. In this study, we investigated the effects of two single nucleotide polymorphisms (SNPs), within the IL-6R loci, previously associated with C-reactive protein (CRP) and coronary heart diseases risk, and with controversial effects on lipids traits: SNP rs4845625 and SNP rs4537545. The results showed that both investigated SNPs were antagonistically related with CRP levels; the minor rs4845625*T allele was associated with increased CRP levels (P-value = 0.011), while the minor rs4537545* T allele was associated with decreased CRP levels (P-value = 0.009). Interestingly, the minor rs4845625* T allele was significantly associated with higher low-density lipoprotein cholesterol (LDL-C) and ApoB levels (P = 0.007 and P = 0.009 respectively). Haplotype analysis showed that the TC haplotype, having the minor rs4845625* T allele, was related simultaneously with increased levels of CRP, LDL-C and ApoB levels, thus could be considered as a risk factor. Our investigation detects for the first time an independent effect of rs4845625 on LDL-C and ApoB traits, explaining an important range of those traits variability (3.49 and 5.57% respectively). Our findings might be of high clinical significance in pharmacogenomics studies of tocilizumab for which IL-6R is target.

AB - Interleukin 6 receptor (IL-6R), mediating IL-6's biological functions, plays an important role in different diseases such as diabetes, obesity and cardio-vascular diseases. In this study, we investigated the effects of two single nucleotide polymorphisms (SNPs), within the IL-6R loci, previously associated with C-reactive protein (CRP) and coronary heart diseases risk, and with controversial effects on lipids traits: SNP rs4845625 and SNP rs4537545. The results showed that both investigated SNPs were antagonistically related with CRP levels; the minor rs4845625*T allele was associated with increased CRP levels (P-value = 0.011), while the minor rs4537545* T allele was associated with decreased CRP levels (P-value = 0.009). Interestingly, the minor rs4845625* T allele was significantly associated with higher low-density lipoprotein cholesterol (LDL-C) and ApoB levels (P = 0.007 and P = 0.009 respectively). Haplotype analysis showed that the TC haplotype, having the minor rs4845625* T allele, was related simultaneously with increased levels of CRP, LDL-C and ApoB levels, thus could be considered as a risk factor. Our investigation detects for the first time an independent effect of rs4845625 on LDL-C and ApoB traits, explaining an important range of those traits variability (3.49 and 5.57% respectively). Our findings might be of high clinical significance in pharmacogenomics studies of tocilizumab for which IL-6R is target.

KW - INTERLEUKIN-6 RECEPTOR GENE

KW - DENSITY-LIPOPROTEIN CHOLESTEROL

KW - CORONARY-HEART-DISEASE

KW - C-REACTIVE PROTEIN

KW - METABOLIC SYNDROME

KW - ASSOCIATION ANALYSES

KW - VARIANTS

KW - INFLAMMATION

KW - POLYMORPHISM

KW - TOCILIZUMAB

U2 - 10.1038/gene.2017.16

DO - 10.1038/gene.2017.16

M3 - Article

VL - 18

SP - 163

EP - 169

JO - GENES AND IMMUNITY

JF - GENES AND IMMUNITY

SN - 1466-4879

IS - 3

ER -

ID: 49367763