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IL6R haplotype rs4845625*T/rs4537545*C is a risk factor for simultaneously high CRP, LDL and ApoB levels

Arguinano, A. A., Naderi, E., Ndiaye, N. C., Stathopoulou, M., Dade, S., Alizadeh, B. & Visvikis-Siesit, S., Oct-2017, In : GENES AND IMMUNITY. 18, 3, p. 163-169 7 p.

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  • IL6R-haplotype-rs4845625T-rs4537545C-is-a-risk-factor-for-simultaneously-high-CRP

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DOI

Interleukin 6 receptor (IL-6R), mediating IL-6's biological functions, plays an important role in different diseases such as diabetes, obesity and cardio-vascular diseases. In this study, we investigated the effects of two single nucleotide polymorphisms (SNPs), within the IL-6R loci, previously associated with C-reactive protein (CRP) and coronary heart diseases risk, and with controversial effects on lipids traits: SNP rs4845625 and SNP rs4537545. The results showed that both investigated SNPs were antagonistically related with CRP levels; the minor rs4845625*T allele was associated with increased CRP levels (P-value = 0.011), while the minor rs4537545* T allele was associated with decreased CRP levels (P-value = 0.009). Interestingly, the minor rs4845625* T allele was significantly associated with higher low-density lipoprotein cholesterol (LDL-C) and ApoB levels (P = 0.007 and P = 0.009 respectively). Haplotype analysis showed that the TC haplotype, having the minor rs4845625* T allele, was related simultaneously with increased levels of CRP, LDL-C and ApoB levels, thus could be considered as a risk factor. Our investigation detects for the first time an independent effect of rs4845625 on LDL-C and ApoB traits, explaining an important range of those traits variability (3.49 and 5.57% respectively). Our findings might be of high clinical significance in pharmacogenomics studies of tocilizumab for which IL-6R is target.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalGENES AND IMMUNITY
Volume18
Issue number3
Publication statusPublished - Oct-2017

    Keywords

  • INTERLEUKIN-6 RECEPTOR GENE, DENSITY-LIPOPROTEIN CHOLESTEROL, CORONARY-HEART-DISEASE, C-REACTIVE PROTEIN, METABOLIC SYNDROME, ASSOCIATION ANALYSES, VARIANTS, INFLAMMATION, POLYMORPHISM, TOCILIZUMAB

ID: 49367763