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Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia

Ivanova, S. A., Osmanova, D. Z., Freidin, M. B., Fedorenko, O. Y., Boiko, A. S., Pozhidaev, I. V., Semke, A. V., Bokhan, N. A., Agarkov, A. A., Wilffert, B. & Loonen, A. J. M., Apr-2017, In : The World Journal of Biological Psychiatry. 18, 3, p. 239-246 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Svetlana A. Ivanova
  • Diana Z. Osmanova
  • Maxim B. Freidin
  • Olga Yu Fedorenko
  • Anastasia S. Boiko
  • Ivan V. Pozhidaev
  • Arkadiy V. Semke
  • Nikolay A. Bokhan
  • Alexey A. Agarkov
  • Bob Wilffert
  • Anton J. M. Loonen

Objectives: Hyperprolactinaemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 subtype receptors in the pituitary gland. Although dopamine is considered the primary factor inhibiting prolactin release, the activity of prolactin-producing lactotrophs is also regulated by the secretagogues thyrotrophin releasing hormone, vasoactive intestinal polypeptide and serotonin (5-hydroxytryptamine; 5-HT).Methods: We describe the association between HPRL and a set of 29 SNPs from 5-HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) who were treated with classical and/or atypical antipsychotic drugs.Results: None of the studied autosomal markers were found to be associated with HPRL. However, a significant association was established between various HTR2C polymorphisms and HPRL.Conclusions: This study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalThe World Journal of Biological Psychiatry
Volume18
Issue number3
Publication statusPublished - Apr-2017

    Keywords

  • antipsychotics, hyperprolactinaemia, polymorphism, schizophrenia, Serotonin receptors, amisulpride, atypical antipsychotic agent, chlorpromazine, chlorprothixene, clozapine, flupentixol decanoate, haloperidol, neuroleptic agent, olanzapine, paliperidone, quetiapine, risperidone, serotonin receptor, sertindole, trifluoperazine, zuclopenthixol, adult, article, Caucasian, chromosome marker, DNA determination, female, gene, gene frequency, gene identification, genetic association, genotype, haplotype, hormone determination, htr1a gene, htr1b gene, htr2a gene, htr2c gene, htr3a gene, htr3b gene, htr6 gene, human, hyperprolactinemia, ICD-10, major clinical study, male, Russian Federation, single nucleotide polymorphism, X chromosome

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