Publication

Identification and Validation of Novel Drug Targets for the Treatment of Plasmodium falciparum Malaria: New Insights

Lunev, S., Batista, F. A., Bosch, S., Wrenger, C. & Groves, M., 30-Nov-2016, Current Topics in Malaria. Rodriguez-Morales, A. (ed.). InTech, p. 235-265 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

  • Sergey Lunev
  • Fernando A. Batista
  • Soraya Bosch
  • Carsten Wrenger
  • Matthew Groves
In order to counter the malarial parasite’s striking ability to rapidly develop drug resistance, a constant supply of novel antimalarial drugs and potential drug targets must be available. The so-called Harlow-Knapp effect, or “searching under the lamp post,” in which scientists tend to further explore only the areas that are already well illuminated, significantly limits the availability of novel drugs and drug targets. This chapter summarizes the pool of electron transport chain (ETC) and carbon metabolism antimalarial targets that have been “under the lamp post” in recent years, as well as suggest a promising new avenue for the validation of novel drug targets. The interplay between the pathways crucial for the parasite, such as pyrimidine biosynthesis, aspartate metabolism, and mitochondrial tricarboxylic acid (TCA) cycle, is described in order to create a “road map” of novel antimalarial avenues.
Original languageEnglish
Title of host publicationCurrent Topics in Malaria
EditorsAlfonso Rodriguez-Morales
PublisherInTech
Pages235-265
Number of pages31
ISBN (Electronic)978-953-51-2790-1
ISBN (Print)978-953-51-2789-5
Publication statusPublished - 30-Nov-2016

    Keywords

  • malaria, Plasmodium falciparum, drug design, drug target validation, protein interference, metabolic map, oligomerization

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