Publication

Hypoxia-inducible factor-1 and neuroglobin expression

Haines, B., Demaria, M., Mao, X., Xie, L., Campisi, J., Jin, K. & Greenberg, D. A., 18-Apr-2012, In : Neuroscience Letters. 514, 2, p. 137-40 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Haines, B., Demaria, M., Mao, X., Xie, L., Campisi, J., Jin, K., & Greenberg, D. A. (2012). Hypoxia-inducible factor-1 and neuroglobin expression. Neuroscience Letters, 514(2), 137-40. https://doi.org/10.1016/j.neulet.2012.01.080

Author

Haines, Bryan ; Demaria, Marco ; Mao, Xiao ; Xie, Lin ; Campisi, Judith ; Jin, Kunlin ; Greenberg, David A. / Hypoxia-inducible factor-1 and neuroglobin expression. In: Neuroscience Letters. 2012 ; Vol. 514, No. 2. pp. 137-40.

Harvard

Haines, B, Demaria, M, Mao, X, Xie, L, Campisi, J, Jin, K & Greenberg, DA 2012, 'Hypoxia-inducible factor-1 and neuroglobin expression' Neuroscience Letters, vol. 514, no. 2, pp. 137-40. https://doi.org/10.1016/j.neulet.2012.01.080

Standard

Hypoxia-inducible factor-1 and neuroglobin expression. / Haines, Bryan; Demaria, Marco; Mao, Xiao; Xie, Lin; Campisi, Judith; Jin, Kunlin; Greenberg, David A.

In: Neuroscience Letters, Vol. 514, No. 2, 18.04.2012, p. 137-40.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Haines B, Demaria M, Mao X, Xie L, Campisi J, Jin K et al. Hypoxia-inducible factor-1 and neuroglobin expression. Neuroscience Letters. 2012 Apr 18;514(2):137-40. https://doi.org/10.1016/j.neulet.2012.01.080


BibTeX

@article{370d54fe8ec24edcbeb6eedace197dc8,
title = "Hypoxia-inducible factor-1 and neuroglobin expression",
abstract = "Neuroglobin (Ngb) is a hypoxia-inducible protein with cytoprotective effects in animal models of stroke, Alzheimer's disease, and related disorders, but the molecular mechanisms involved in its induction are unknown. We tested the hypothesis that hypoxia-inducible factor-1 (HIF-1) regulates Ngb levels, using shRNA-mediated knockdown and lentiviral vector-mediated overexpression of the HIF-1α subunit, in cultured neural (HN33) cells. HIF-1α knockdown decreased and HIF-1α overexpression increased Ngb levels, consistent with a connection between HIF-1 and Ngb induction. These findings may have implications for understanding the hypoxia-response repertoire of neural cells and devising therapeutic strategies for neurologic disorders.",
keywords = "Animals, Cell Line, Cells, Cultured, Globins, Hippocampus, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Nerve Tissue Proteins, RNA, Small Interfering",
author = "Bryan Haines and Marco Demaria and Xiao Mao and Lin Xie and Judith Campisi and Kunlin Jin and Greenberg, {David A}",
note = "Copyright {\circledC} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2012",
month = "4",
day = "18",
doi = "10.1016/j.neulet.2012.01.080",
language = "English",
volume = "514",
pages = "137--40",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "ELSEVIER IRELAND LTD",
number = "2",

}

RIS

TY - JOUR

T1 - Hypoxia-inducible factor-1 and neuroglobin expression

AU - Haines, Bryan

AU - Demaria, Marco

AU - Mao, Xiao

AU - Xie, Lin

AU - Campisi, Judith

AU - Jin, Kunlin

AU - Greenberg, David A

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2012/4/18

Y1 - 2012/4/18

N2 - Neuroglobin (Ngb) is a hypoxia-inducible protein with cytoprotective effects in animal models of stroke, Alzheimer's disease, and related disorders, but the molecular mechanisms involved in its induction are unknown. We tested the hypothesis that hypoxia-inducible factor-1 (HIF-1) regulates Ngb levels, using shRNA-mediated knockdown and lentiviral vector-mediated overexpression of the HIF-1α subunit, in cultured neural (HN33) cells. HIF-1α knockdown decreased and HIF-1α overexpression increased Ngb levels, consistent with a connection between HIF-1 and Ngb induction. These findings may have implications for understanding the hypoxia-response repertoire of neural cells and devising therapeutic strategies for neurologic disorders.

AB - Neuroglobin (Ngb) is a hypoxia-inducible protein with cytoprotective effects in animal models of stroke, Alzheimer's disease, and related disorders, but the molecular mechanisms involved in its induction are unknown. We tested the hypothesis that hypoxia-inducible factor-1 (HIF-1) regulates Ngb levels, using shRNA-mediated knockdown and lentiviral vector-mediated overexpression of the HIF-1α subunit, in cultured neural (HN33) cells. HIF-1α knockdown decreased and HIF-1α overexpression increased Ngb levels, consistent with a connection between HIF-1 and Ngb induction. These findings may have implications for understanding the hypoxia-response repertoire of neural cells and devising therapeutic strategies for neurologic disorders.

KW - Animals

KW - Cell Line

KW - Cells, Cultured

KW - Globins

KW - Hippocampus

KW - Hypoxia-Inducible Factor 1, alpha Subunit

KW - Mice

KW - Nerve Tissue Proteins

KW - RNA, Small Interfering

U2 - 10.1016/j.neulet.2012.01.080

DO - 10.1016/j.neulet.2012.01.080

M3 - Article

VL - 514

SP - 137

EP - 140

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -

ID: 26938197