Publication

Hypothalamic-pituitary-adrenal axis and smoking and drinking onset among adolescents: the longitudinal cohort TRacking Adolescents' Individual Lives Survey (TRAILS)

Huizink, A., Greaves-Lord, K., Oldehinkel, A. J., Ormel, J. & Verhulst, F. C., Nov-2009, In : Addiction. 104, 11, p. 1927-1936 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Huizink_2009_Addiction.pdf

    Final publisher's version, 140 KB, PDF document

    Request copy

DOI

Aims

We examined within a prospective longitudinal study whether cortisol levels were associated with smoking or drinking behaviours, taking parental substance use into account.

Design

The influence of parental substance use on cortisol levels of their adolescent offspring at age 10-12 years was examined. Next, cortisol levels of adolescents who initiated smoking or drinking at the first data collection (age 10-12) were compared to non-users. Finally, we examined whether cortisol levels could predict new onset and frequency of smoking and drinking 2 years later.

Setting and participants

First and second assessment data of the TRacking Adolescents' Individual Lives Survey (TRAILS) were used, including 1768 Dutch adolescents aged 10-12 years, who were followed-up across a period of 2 years.

Measurements

Cortisol was measured in saliva samples at awakening, 30 minutes later, and at 8 p.m. at age 10-12. Self-reported substance use at age 10-12 and 13-14, and parental self-reported substance use were used.

Findings

Only maternal substance use was related to slightly lower adolescent cortisol levels at 8 p.m. Both maternal and paternal substance use were associated with adolescent smoking and drinking at age 13-14, although fathers' use only predicted the amount used and not the chance of ever use. Finally, higher cortisol levels were related moderately to current smoking and future frequency of smoking, but not to alcohol use.

Conclusions

In a general population, parental heavy substance use does not seem to affect cortisol levels consistently in their offspring. We found some evidence for higher, instead of lower, hypothalamic-pituitary-adrenal axis activity as a predictor of smoking in early adolescence.

Original languageEnglish
Pages (from-to)1927-1936
Number of pages10
JournalAddiction
Volume104
Issue number11
Publication statusPublished - Nov-2009

    Keywords

  • Adolescents, cortisol, drinking, drinking onset, HPA axis, smoking, smoking onset, SALIVARY CORTISOL RESPONSES, ALCOHOL-DEPENDENT MEN, HPA AXIS, SOBER ALCOHOLICS, PREPUBERTAL BOYS, SUBSTANCE-ABUSE, CANNABIS USE, STRESS, RISK, NICOTINE

ID: 2009119