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Hydrogen sulfide producing enzymes in pregnancy and preeclampsia

Holwerda, K. M., Bos, E. M., Rajakumar, A., Ris-Stalpers, C., van Pampus, M. G., Timmer, A., Erwich, J. J. H. M., Faas, M. M., van Goor, H. & Lely, A. T., Jun-2012, In : Placenta. 33, 6, p. 518-521 4 p.

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DOI

Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H(2)S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H(2)S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H(2)S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H(2)S-production and may aid in the anti-angiogenic state.

Original languageEnglish
Pages (from-to)518-521
Number of pages4
JournalPlacenta
Volume33
Issue number6
Publication statusPublished - Jun-2012

    Keywords

  • Hydrogen sulfide, Cysthationine-beta-synthase, Cysthationine-gamma-lyase, Preeclampsia, Endothelial dysfunction, HYPERTENSION, EXPRESSION, METABOLISM, DISEASE, GROWTH, CELLS, MICE, H2S

ID: 2432596