Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalystGuo, B., de Vries, J. G. & Otten, E., 7-Dec-2019, In : Chemical Science. 10, 45, p. 10647-10652 6 p.
Research output: Contribution to journal › Article › Academic › peer-review
Nitrile hydration provides access to amides that are important structural elements in organic chemistry. Here we report catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyze the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in (BuOH)-Bu-t as solvent. Reactions occur under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration is proposed that is initiated by metal-ligand cooperative binding of the nitrile.
|Number of pages||6|
|Publication status||Published - 7-Dec-2019|
- BOND FORMATION, TEMPLATE CATALYSIS, MICHAEL ADDITIONS, WATER ACTIVATION, COMPLEXES, HYDROLYSIS, AMINO, ACID, CO2, RU