Publication

Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment

Kracht, L., Borggrewe, M., Eskandar, S., Brouwer, N., Chuva de Sousa Lopes, S. M., Laman, J. D., Scherjon, S. A., Prins, J. R., Kooistra, S. M. & Eggen, B. J. L., 31-Jul-2020, In : Science. 369, 6503, p. 530-537 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Kracht, L., Borggrewe, M., Eskandar, S., Brouwer, N., Chuva de Sousa Lopes, S. M., Laman, J. D., Scherjon, S. A., Prins, J. R., Kooistra, S. M., & Eggen, B. J. L. (2020). Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment. Science, 369(6503), 530-537. https://doi.org/10.1126/science.aba5906

Author

Kracht, L ; Borggrewe, M ; Eskandar, S ; Brouwer, N ; Chuva de Sousa Lopes, S M ; Laman, J D ; Scherjon, S A ; Prins, J R ; Kooistra, S M ; Eggen, B J L. / Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment. In: Science. 2020 ; Vol. 369, No. 6503. pp. 530-537.

Harvard

Kracht, L, Borggrewe, M, Eskandar, S, Brouwer, N, Chuva de Sousa Lopes, SM, Laman, JD, Scherjon, SA, Prins, JR, Kooistra, SM & Eggen, BJL 2020, 'Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment', Science, vol. 369, no. 6503, pp. 530-537. https://doi.org/10.1126/science.aba5906

Standard

Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment. / Kracht, L; Borggrewe, M; Eskandar, S; Brouwer, N; Chuva de Sousa Lopes, S M; Laman, J D; Scherjon, S A; Prins, J R; Kooistra, S M; Eggen, B J L.

In: Science, Vol. 369, No. 6503, 31.07.2020, p. 530-537.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Kracht L, Borggrewe M, Eskandar S, Brouwer N, Chuva de Sousa Lopes SM, Laman JD et al. Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment. Science. 2020 Jul 31;369(6503):530-537. https://doi.org/10.1126/science.aba5906


BibTeX

@article{bfd72733be3f4ebb959934e5c323a589,
title = "Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment",
abstract = "Microglia, immune cells of the central nervous system (CNS), are important for tissue development and maintenance and are implicated in CNS disease, but we lack understanding of human fetal microglia development. Single-cell gene expression and bulk chromatin profiles of microglia at 9 to 18 gestational weeks (GWs) of human fetal development were generated. Microglia were heterogeneous at all studied GWs. Microglia start to mature during this developmental period and increasingly resemble adult microglia with CNS-surveilling properties. Chromatin accessibility increases during development with associated transcriptional networks reflective of adult microglia. Thus, during early fetal development, microglia progress toward a more mature, immune-sensing competent phenotype, and this might render the developing human CNS vulnerable to environmental perturbations during early pregnancy.",
keywords = "READ ALIGNMENT, RNA-SEQ, DIFFERENTIATION, MYELINOGENESIS, TURNOVER, BINDING, CELLS, PU.1, AGE",
author = "L Kracht and M Borggrewe and S Eskandar and N Brouwer and {Chuva de Sousa Lopes}, {S M} and Laman, {J D} and Scherjon, {S A} and Prins, {J R} and Kooistra, {S M} and Eggen, {B J L}",
note = "Copyright {\textcopyright} 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2020",
month = jul,
day = "31",
doi = "10.1126/science.aba5906",
language = "English",
volume = "369",
pages = "530--537",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6503",

}

RIS

TY - JOUR

T1 - Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment

AU - Kracht, L

AU - Borggrewe, M

AU - Eskandar, S

AU - Brouwer, N

AU - Chuva de Sousa Lopes, S M

AU - Laman, J D

AU - Scherjon, S A

AU - Prins, J R

AU - Kooistra, S M

AU - Eggen, B J L

N1 - Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

PY - 2020/7/31

Y1 - 2020/7/31

N2 - Microglia, immune cells of the central nervous system (CNS), are important for tissue development and maintenance and are implicated in CNS disease, but we lack understanding of human fetal microglia development. Single-cell gene expression and bulk chromatin profiles of microglia at 9 to 18 gestational weeks (GWs) of human fetal development were generated. Microglia were heterogeneous at all studied GWs. Microglia start to mature during this developmental period and increasingly resemble adult microglia with CNS-surveilling properties. Chromatin accessibility increases during development with associated transcriptional networks reflective of adult microglia. Thus, during early fetal development, microglia progress toward a more mature, immune-sensing competent phenotype, and this might render the developing human CNS vulnerable to environmental perturbations during early pregnancy.

AB - Microglia, immune cells of the central nervous system (CNS), are important for tissue development and maintenance and are implicated in CNS disease, but we lack understanding of human fetal microglia development. Single-cell gene expression and bulk chromatin profiles of microglia at 9 to 18 gestational weeks (GWs) of human fetal development were generated. Microglia were heterogeneous at all studied GWs. Microglia start to mature during this developmental period and increasingly resemble adult microglia with CNS-surveilling properties. Chromatin accessibility increases during development with associated transcriptional networks reflective of adult microglia. Thus, during early fetal development, microglia progress toward a more mature, immune-sensing competent phenotype, and this might render the developing human CNS vulnerable to environmental perturbations during early pregnancy.

KW - READ ALIGNMENT

KW - RNA-SEQ

KW - DIFFERENTIATION

KW - MYELINOGENESIS

KW - TURNOVER

KW - BINDING

KW - CELLS

KW - PU.1

KW - AGE

U2 - 10.1126/science.aba5906

DO - 10.1126/science.aba5906

M3 - Article

C2 - 32732419

VL - 369

SP - 530

EP - 537

JO - Science

JF - Science

SN - 0036-8075

IS - 6503

ER -

ID: 130693985