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HSP40/DNAJ Chaperones
Bergink, S., Kampinga, H. H., Kolbe Musskopf, M. & Preusser Mattos, E., 17-May-2018, In : eLS.Research output: Contribution to journal › Article › Academic › peer-review
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HSP40/DNAJ Chaperones. / Bergink, Steven; Kampinga, H.H.; Kolbe Musskopf, Maiara; Preusser Mattos, Eduardo.
In: eLS, 17.05.2018.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - HSP40/DNAJ Chaperones
AU - Bergink, Steven
AU - Kampinga, H.H.
AU - Kolbe Musskopf, Maiara
AU - Preusser Mattos, Eduardo
PY - 2018/5/17
Y1 - 2018/5/17
N2 - Members of the HSP40/DNAJ family comprise oneof the largest groups of molecular chaperones, andare present in all living organisms from bacteriato humans. The hallmark of DNAJs is the presenceof a J-domain, which is crucial for interaction withHSP70. DNAJs can be seen as the workforce thatsteers HSP70 machines, regulating client input andspecificity. The different DNAJs are involved in processessuch as (re)folding, intracellular transportacross membranes, protein modifications, remodellingof protein complexes and protein degradation.In particular, different DNAJs are able tosuppress aggregate formation of several amyloidogenicproteins linked to human diseases. On theother hand, mutations in many DNAJs give rise to awide range of pathologies, attesting to their fundamentalrole in cellular homeostasis and generalprotein quality control.
AB - Members of the HSP40/DNAJ family comprise oneof the largest groups of molecular chaperones, andare present in all living organisms from bacteriato humans. The hallmark of DNAJs is the presenceof a J-domain, which is crucial for interaction withHSP70. DNAJs can be seen as the workforce thatsteers HSP70 machines, regulating client input andspecificity. The different DNAJs are involved in processessuch as (re)folding, intracellular transportacross membranes, protein modifications, remodellingof protein complexes and protein degradation.In particular, different DNAJs are able tosuppress aggregate formation of several amyloidogenicproteins linked to human diseases. On theother hand, mutations in many DNAJs give rise to awide range of pathologies, attesting to their fundamentalrole in cellular homeostasis and generalprotein quality control.
U2 - 10.1002/9780470015902.a0027633
DO - 10.1002/9780470015902.a0027633
M3 - Article
JO - eLS
JF - eLS
ER -
ID: 83112308