How amyloid precursor protein protects itself from cleavageLin, H-K. & van der Wel, P. C. A., Mar-2014, In : Structure. 22, 3, p. 361-362 2 p.
Research output: Contribution to journal › Article › Academic
In this issue of Structure, Tang and colleagues probe how the Flemish mutation in amyloid precursor protein (APP) affects its conformation and cleavage by γ-secretase. They provide molecular insight into how an extracellular inhibitory element and cholesterol interactions affect the generation of Aβ peptides.
|Number of pages||2|
|Publication status||Published - Mar-2014|
- Amyloid beta-Peptides/biosynthesis, Amyloid beta-Protein Precursor/chemistry, Animals, Humans, Mutation, TRANSMEMBRANE DOMAIN, CHOLESTEROL, FLEMISH