How amyloid precursor protein protects itself from cleavage

Lin, H-K. & van der Wel, P. C. A., Mar-2014, In : Structure. 22, 3, p. 361-362 2 p.

Research output: Contribution to journalArticleAcademic

Copy link to clipboard


  • How Amyloid Precursor Protein Protects Itself from Cleavage

    Final publisher's version, 427 KB, PDF document


In this issue of Structure, Tang and colleagues probe how the Flemish mutation in amyloid precursor protein (APP) affects its conformation and cleavage by γ-secretase. They provide molecular insight into how an extracellular inhibitory element and cholesterol interactions affect the generation of Aβ peptides.
Original languageEnglish
Pages (from-to)361-362
Number of pages2
Issue number3
Publication statusPublished - Mar-2014
Externally publishedYes


  • Amyloid beta-Peptides/biosynthesis, Amyloid beta-Protein Precursor/chemistry, Animals, Humans, Mutation, TRANSMEMBRANE DOMAIN, CHOLESTEROL, FLEMISH

ID: 64377424