Host organisms: Bacillus subtilis

Hohman, H-P., van Dijl, J., Krishnappa, L. & Pragai, Z., 2016, Industrial Biotechnology: Microorganisms. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 1. p. 221-297 77 p.

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  • Host Organisms Bacillus subtilis

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Bacillus subtilis and its close Bacillus relatives are important bacterial platforms for industrial production of enzymes and fine chemicals such as vitamin B2 and nucleotides. B. subtilis is an attractive bacterial organism for industrial use mainly because of its straightforward genetic manipulation, favorable growth characteristics in industrial scale fermentations, its ability to produce and secrete proteins and fine chemicals outside the cell and its high level of safety with the generally recognized as safe (GRAS) status attributed to many of its products. Since centuries the “natto” subspecies of B. subtilis is used for the fermentative production of natto, a traditional Japanese soya-based food product. Moreover, B. subtilis is also the Gram-positive model organism for basic research in biochemistry, genetics, and molecular biology. Here, we review advances in the application of B. subtilis for the production of proteins and fine chemicals with special emphasis on the methodologies that can be applied to improve this versatile cell factory.
Original languageEnglish
Title of host publicationIndustrial Biotechnology
Subtitle of host publicationMicroorganisms
Place of PublicationWeinheim, Germany
PublisherWiley-VCH Verlag GmbH & Co. KGaA
Number of pages77
ISBN (Electronic)9783527807796
ISBN (Print)9783527341795
Publication statusPublished - 2016

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