Publication

Hodgkin's disease: A tumor with disturbed immunological pathways

Gruss, HJ., Pinto, A., Duyster, J., Poppema, S. & Herrmann, F., Apr-1997, In : Immunology Today. 18, 4, p. 156-163 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • HJ Gruss
  • A Pinto
  • J Duyster
  • S Poppema
  • F Herrmann

Hodgkin's disease is a lymphoid neoplasia characterized by a low frequency of malignant Hodgkin and Reed-Sternberg (H-RS) cells in an abundant background of non-neoplastic cells. H-RS cells and their neighbors interact via a complex network of cellular activation/adhesion molecules and cytokines. Here, Hans-Jurgen Gruss and colleagues suggest that H-RS cells can be regarded as antigen-presenting cells able to interact with surrounding T cells, resulting in an intense, but ineffective, immune response.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalImmunology Today
Volume18
Issue number4
Publication statusPublished - Apr-1997

    Keywords

  • REED-STERNBERG CELLS, EPSTEIN-BARR-VIRUS, NODULAR LYMPHOCYTE PREDOMINANCE, ANAPLASTIC LARGE-CELL, MALIGNANT-LYMPHOMAS, T-CELLS, CYTOKINE RECEPTOR, CD30 ANTIGEN, CD40 LIGAND, B-CELLS

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