Hodgkin's disease: A tumor with disturbed immunological pathwaysGruss, H. J., Pinto, A., Duyster, J., Poppema, S. & Herrmann, F. Apr-1997 In : Immunology Today. 18, 4, p. 156-163 8 p.
Research output: Contribution to journal › Article
Hodgkin's disease is a lymphoid neoplasia characterized by a low frequency of malignant Hodgkin and Reed-Sternberg (H-RS) cells in an abundant background of non-neoplastic cells. H-RS cells and their neighbors interact via a complex network of cellular activation/adhesion molecules and cytokines. Here, Hans-Jurgen Gruss and colleagues suggest that H-RS cells can be regarded as antigen-presenting cells able to interact with surrounding T cells, resulting in an intense, but ineffective, immune response.
|Number of pages||8|
|State||Published - Apr-1997|
- REED-STERNBERG CELLS, EPSTEIN-BARR-VIRUS, NODULAR LYMPHOCYTE PREDOMINANCE, ANAPLASTIC LARGE-CELL, MALIGNANT-LYMPHOMAS, T-CELLS, CYTOKINE RECEPTOR, CD30 ANTIGEN, CD40 LIGAND, B-CELLS