Publication

Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation

Ghizzoni, M., Haisma, H. J., Maarsingh, H. & Dekker, F. J., Jun-2011, In : Drug Discovery Today. 16, 11-12, p. 504-511 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Ghizzoni, M., Haisma, H. J., Maarsingh, H., & Dekker, F. J. (2011). Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation. Drug Discovery Today, 16(11-12), 504-511. https://doi.org/10.1016/j.drudis.2011.03.009

Author

Ghizzoni, Massimo ; Haisma, Hidde J. ; Maarsingh, Harm ; Dekker, Frank J. / Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation. In: Drug Discovery Today. 2011 ; Vol. 16, No. 11-12. pp. 504-511.

Harvard

Ghizzoni, M, Haisma, HJ, Maarsingh, H & Dekker, FJ 2011, 'Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation', Drug Discovery Today, vol. 16, no. 11-12, pp. 504-511. https://doi.org/10.1016/j.drudis.2011.03.009

Standard

Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation. / Ghizzoni, Massimo; Haisma, Hidde J.; Maarsingh, Harm; Dekker, Frank J.

In: Drug Discovery Today, Vol. 16, No. 11-12, 06.2011, p. 504-511.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Ghizzoni M, Haisma HJ, Maarsingh H, Dekker FJ. Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation. Drug Discovery Today. 2011 Jun;16(11-12):504-511. https://doi.org/10.1016/j.drudis.2011.03.009


BibTeX

@article{3190a685c6f64a728bb8887c5aba30a8,
title = "Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation",
abstract = "Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.",
keywords = "DEPENDENT GENE-EXPRESSION, CREB-BINDING PROTEIN, SMOOTH-MUSCLE-CELLS, H4 ACETYLATION, ANACARDIC ACID, IN-VIVO, TRANSCRIPTIONAL ACTIVATION, CHROMATIN TRANSCRIPTION, DEACETYLASE ACTIVITY, LUNG INFLAMMATION",
author = "Massimo Ghizzoni and Haisma, {Hidde J.} and Harm Maarsingh and Dekker, {Frank J.}",
year = "2011",
month = "6",
doi = "10.1016/j.drudis.2011.03.009",
language = "English",
volume = "16",
pages = "504--511",
journal = "Drug Discovery Today",
issn = "1359-6446",
publisher = "ELSEVIER SCI LTD",
number = "11-12",

}

RIS

TY - JOUR

T1 - Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation

AU - Ghizzoni, Massimo

AU - Haisma, Hidde J.

AU - Maarsingh, Harm

AU - Dekker, Frank J.

PY - 2011/6

Y1 - 2011/6

N2 - Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.

AB - Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.

KW - DEPENDENT GENE-EXPRESSION

KW - CREB-BINDING PROTEIN

KW - SMOOTH-MUSCLE-CELLS

KW - H4 ACETYLATION

KW - ANACARDIC ACID

KW - IN-VIVO

KW - TRANSCRIPTIONAL ACTIVATION

KW - CHROMATIN TRANSCRIPTION

KW - DEACETYLASE ACTIVITY

KW - LUNG INFLAMMATION

U2 - 10.1016/j.drudis.2011.03.009

DO - 10.1016/j.drudis.2011.03.009

M3 - Review article

VL - 16

SP - 504

EP - 511

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 11-12

ER -

ID: 5354065