Publication

Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation

Ghizzoni, M., Haisma, H. J., Maarsingh, H. & Dekker, F. J., Jun-2011, In : Drug Discovery Today. 16, 11-12, p. 504-511 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.

Original languageEnglish
Pages (from-to)504-511
Number of pages8
JournalDrug Discovery Today
Volume16
Issue number11-12
Publication statusPublished - Jun-2011

    Keywords

  • DEPENDENT GENE-EXPRESSION, CREB-BINDING PROTEIN, SMOOTH-MUSCLE-CELLS, H4 ACETYLATION, ANACARDIC ACID, IN-VIVO, TRANSCRIPTIONAL ACTIVATION, CHROMATIN TRANSCRIPTION, DEACETYLASE ACTIVITY, LUNG INFLAMMATION

View graph of relations

ID: 5354065