Publication

Hippocampal gamma oscillations increase with memory load

Van Vugt, M. K., Schulze-Bonhage, A., Litt, B., Brandt, A. & Kahana, M. J., 17-Feb-2010, In : The Journal of Neuroscience. 30, 7, p. 2694-2699 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Although the hippocampus plays a crucial role in encoding and retrieval of contextually mediated episodic memories, considerable controversy surrounds the role of the hippocampus in short-term or working memory. To examine both hippocampal and neocortical contributions to working memory function, we recorded electrocorticographic activity from widespread cortical and subcortical sites as 20 neurosurgical patients performed working memory tasks. These recordings revealed significant increases in 48-90 Hz gamma oscillatory power with memory load for two classes of stimuli: letters and faces. Sites exhibiting gamma increases with memory load appeared primarily in the hippocampus and medial temporal lobe. These findings implicate gamma oscillatory activity in the maintenance of both letters and faces in working memory and provide the first direct evidence for modulation of hippocampal gamma oscillations as humans perform a working memory task. Copyright © 2010 the authors.
Original languageEnglish
Pages (from-to)2694-2699
Number of pages6
JournalThe Journal of Neuroscience
Volume30
Issue number7
Publication statusPublished - 17-Feb-2010

    Keywords

  • SHORT-TERM-MEMORY, MATCHING-TO-SAMPLE, WORKING-MEMORY, RECOGNITION MEMORY, NEURAL REPRESENTATION, BRAIN OSCILLATIONS, PREFRONTAL CORTEX, AMNESIC SUBJECTS, CONTEXT, EEG

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