Publication

High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke

MR CLEAN Registry Investigators, Autar, A. S. A., Hund, H. M., Ramlal, S. A., Hansen, D., Lycklama À Nijeholt, G. J., Emmer, B. J., de Maat, M. P. M., Dippel, D. W. J., van der Lugt, A., van Es, A. C. G. M. & van Beusekom, H. M. M., 22-Jun-2018, In : Journal of the American Heart Association. 7, 13, 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

MR CLEAN Registry Investigators, Autar, A. S. A., Hund, H. M., Ramlal, S. A., Hansen, D., Lycklama À Nijeholt, G. J., Emmer, B. J., de Maat, M. P. M., Dippel, D. W. J., van der Lugt, A., van Es, A. C. G. M., & van Beusekom, H. M. M. (2018). High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke. Journal of the American Heart Association, 7(13). https://doi.org/10.1161/JAHA.118.008563

Author

MR CLEAN Registry Investigators ; Autar, Anouchska S A ; Hund, Hajo M ; Ramlal, Sharad A ; Hansen, Daniël ; Lycklama À Nijeholt, Geert J ; Emmer, Bart J ; de Maat, Moniek P M ; Dippel, Diederik W J ; van der Lugt, Aad ; van Es, Adriaan C G M ; van Beusekom, Heleen M M. / High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke. In: Journal of the American Heart Association. 2018 ; Vol. 7, No. 13.

Harvard

MR CLEAN Registry Investigators, Autar, ASA, Hund, HM, Ramlal, SA, Hansen, D, Lycklama À Nijeholt, GJ, Emmer, BJ, de Maat, MPM, Dippel, DWJ, van der Lugt, A, van Es, ACGM & van Beusekom, HMM 2018, 'High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke', Journal of the American Heart Association, vol. 7, no. 13. https://doi.org/10.1161/JAHA.118.008563

Standard

High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke. / MR CLEAN Registry Investigators; Autar, Anouchska S A; Hund, Hajo M; Ramlal, Sharad A; Hansen, Daniël; Lycklama À Nijeholt, Geert J; Emmer, Bart J; de Maat, Moniek P M; Dippel, Diederik W J; van der Lugt, Aad; van Es, Adriaan C G M; van Beusekom, Heleen M M.

In: Journal of the American Heart Association, Vol. 7, No. 13, 22.06.2018.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

MR CLEAN Registry Investigators, Autar ASA, Hund HM, Ramlal SA, Hansen D, Lycklama À Nijeholt GJ et al. High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke. Journal of the American Heart Association. 2018 Jun 22;7(13). https://doi.org/10.1161/JAHA.118.008563


BibTeX

@article{87415d118a164337a2ff76a2651e6047,
title = "High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke",
abstract = "BACKGROUND: Currently, acute ischemic stroke is still a leading cause of mortality and morbidity. Approximately 2 years ago, mechanical thrombectomy was proven beneficial as a revolutionary new therapy for stroke in the MR-CLEAN trial (A Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). However, the mechanisms by which the thrombectomy device, or stent-retriever, interacts with the thrombus are largely unknown. A better understanding could lead to improved efficacy of mechanical thrombectomy devices.METHODS AND RESULTS: Seven stent-retrievers with thrombi still entrapped were collected directly after thrombectomy. The stent-retrievers were studied using micro computed tomography, followed by scanning electron microscopy and light microscopy. Two independent observers rated interaction type and thrombus surface structure (porous filamentous or dense) at the interaction sites.A total of 79 interaction sites between thrombus and stent-retriever were categorized. Thrombus-stent-retriever interaction was found to be adhesive (n=44; 56%) or mechanical (n=35; 44%). Adhesive interaction was most frequently observed at interaction sites with a dense surface, compared with interaction sites with a porous filamentous fibrin surface (38/58; 66% versus 6/21; 29%, P=0.011).CONCLUSIONS: The interaction between thrombus and stent-retriever was predominantly adhesive, not mechanical. Adhesive interaction was strongly associated with the presence of a dense thrombus surface without a porous filamentous fibrin network.",
author = "{MR CLEAN Registry Investigators} and Autar, {Anouchska S A} and Hund, {Hajo M} and Ramlal, {Sharad A} and Dani{\"e}l Hansen and {Lycklama {\`A} Nijeholt}, {Geert J} and Emmer, {Bart J} and {de Maat}, {Moniek P M} and Dippel, {Diederik W J} and {van der Lugt}, Aad and {van Es}, {Adriaan C G M} and {van Beusekom}, {Heleen M M} and Maarten Uyttenboogaart",
note = "{\textcopyright} 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.",
year = "2018",
month = jun,
day = "22",
doi = "10.1161/JAHA.118.008563",
language = "English",
volume = "7",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley",
number = "13",

}

RIS

TY - JOUR

T1 - High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke

AU - MR CLEAN Registry Investigators

AU - Autar, Anouchska S A

AU - Hund, Hajo M

AU - Ramlal, Sharad A

AU - Hansen, Daniël

AU - Lycklama À Nijeholt, Geert J

AU - Emmer, Bart J

AU - de Maat, Moniek P M

AU - Dippel, Diederik W J

AU - van der Lugt, Aad

AU - van Es, Adriaan C G M

AU - van Beusekom, Heleen M M

AU - Uyttenboogaart, Maarten

N1 - © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

PY - 2018/6/22

Y1 - 2018/6/22

N2 - BACKGROUND: Currently, acute ischemic stroke is still a leading cause of mortality and morbidity. Approximately 2 years ago, mechanical thrombectomy was proven beneficial as a revolutionary new therapy for stroke in the MR-CLEAN trial (A Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). However, the mechanisms by which the thrombectomy device, or stent-retriever, interacts with the thrombus are largely unknown. A better understanding could lead to improved efficacy of mechanical thrombectomy devices.METHODS AND RESULTS: Seven stent-retrievers with thrombi still entrapped were collected directly after thrombectomy. The stent-retrievers were studied using micro computed tomography, followed by scanning electron microscopy and light microscopy. Two independent observers rated interaction type and thrombus surface structure (porous filamentous or dense) at the interaction sites.A total of 79 interaction sites between thrombus and stent-retriever were categorized. Thrombus-stent-retriever interaction was found to be adhesive (n=44; 56%) or mechanical (n=35; 44%). Adhesive interaction was most frequently observed at interaction sites with a dense surface, compared with interaction sites with a porous filamentous fibrin surface (38/58; 66% versus 6/21; 29%, P=0.011).CONCLUSIONS: The interaction between thrombus and stent-retriever was predominantly adhesive, not mechanical. Adhesive interaction was strongly associated with the presence of a dense thrombus surface without a porous filamentous fibrin network.

AB - BACKGROUND: Currently, acute ischemic stroke is still a leading cause of mortality and morbidity. Approximately 2 years ago, mechanical thrombectomy was proven beneficial as a revolutionary new therapy for stroke in the MR-CLEAN trial (A Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). However, the mechanisms by which the thrombectomy device, or stent-retriever, interacts with the thrombus are largely unknown. A better understanding could lead to improved efficacy of mechanical thrombectomy devices.METHODS AND RESULTS: Seven stent-retrievers with thrombi still entrapped were collected directly after thrombectomy. The stent-retrievers were studied using micro computed tomography, followed by scanning electron microscopy and light microscopy. Two independent observers rated interaction type and thrombus surface structure (porous filamentous or dense) at the interaction sites.A total of 79 interaction sites between thrombus and stent-retriever were categorized. Thrombus-stent-retriever interaction was found to be adhesive (n=44; 56%) or mechanical (n=35; 44%). Adhesive interaction was most frequently observed at interaction sites with a dense surface, compared with interaction sites with a porous filamentous fibrin surface (38/58; 66% versus 6/21; 29%, P=0.011).CONCLUSIONS: The interaction between thrombus and stent-retriever was predominantly adhesive, not mechanical. Adhesive interaction was strongly associated with the presence of a dense thrombus surface without a porous filamentous fibrin network.

U2 - 10.1161/JAHA.118.008563

DO - 10.1161/JAHA.118.008563

M3 - Article

C2 - 29934420

VL - 7

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 13

ER -

ID: 64563291