Highlighting the role of Ras and Rap during Dictyostelium chemotaxisKortholt, A. & van Haastert, P. J. M., Aug-2008, In : Cellular Signalling. 20, 8, p. 1415-1422 8 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis. (c) 2008 Elsevier Inc. All rights reserved.
|Number of pages||8|
|Publication status||Published - Aug-2008|
- Dictyostelium, chemotaxis, Ras, Rap, guanine exchange factor, GTP-binding protein, RECEPTOR-MEDIATED ACTIVATION, HETEROTRIMERIC G-PROTEINS, CONTROLS CELL-ADHESION, BETA-GAMMA-SUBUNITS, HEAVY-CHAIN KINASE, ADENYLYL-CYCLASE, SIGNAL-TRANSDUCTION, PHOSPHOLIPASE-C, MYOSIN-II, CHEMOATTRACTANT RECEPTORS