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Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

Kortholt, A. & van Haastert, P. J. M., Aug-2008, In : Cellular Signalling. 20, 8, p. 1415-1422 8 p.

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DOI

Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis. (c) 2008 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)1415-1422
Number of pages8
JournalCellular Signalling
Volume20
Issue number8
Publication statusPublished - Aug-2008

    Keywords

  • Dictyostelium, chemotaxis, Ras, Rap, guanine exchange factor, GTP-binding protein, RECEPTOR-MEDIATED ACTIVATION, HETEROTRIMERIC G-PROTEINS, CONTROLS CELL-ADHESION, BETA-GAMMA-SUBUNITS, HEAVY-CHAIN KINASE, ADENYLYL-CYCLASE, SIGNAL-TRANSDUCTION, PHOSPHOLIPASE-C, MYOSIN-II, CHEMOATTRACTANT RECEPTORS

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