Publication

HIGHER ANTI-HEPARAN SULFATE REACTIVITY DURING SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) DISEASE EXACERBATIONS WITH RENAL MANIFESTATIONS - A LONG-TERM PROSPECTIVE ANALYSIS

KRAMERS, C., TERMAAT, RM., TERBORG, EJ., VANBRUGGEN, MCJ., KALLENBERG, CGM. & BERDEN, JHM., Jul-1993, In : Clinical and Experimental Immunology. 93, 1, p. 34-38 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • C KRAMERS
  • RM TERMAAT
  • EJ TERBORG
  • MCJ VANBRUGGEN
  • CGM KALLENBERG
  • JHM BERDEN

Cross-reactive antibodies against heparan sulphate (HS) have been suggested to play a role in initiating renal disease in SLE. Recently, we found that HS-reactivity is mediated by anti-DNA antibodies complexed with DNA and histones. To evaluate the clinical significance of anti-HS reactivity, we studied prospectively a cohort of 72 consecutive SLE patients, of whom 22 experienced 40 exacerbations. In 20 of these exacerbations renal symptoms were present. In these 20 exacerbations significantly higher anti-DNA (median 1:160) and anti-HS (median 1:30) titres were detected compared with exacerbations without renal manifestations (median 1:60 for anti-DNA and negative for anti-HS). There were no correlations with other symptoms of SLE. Anti-HS titres showed a significant correlation with anti-DNA antibody titres (r(s) = 0-57, P <0.05). Anti-HS without anti-DNA reactivity was never detected. Some SLE patients showed a high anti-DNA titre without anti-HS reactivity, suggesting that not all anti-DNA antibodies are able to bind to histone/DNA complexes and thus to exhibit anti-HS reactivity. Our findings indicate that anti-HS reactivity is correlated with renal disease in SLE.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalClinical and Experimental Immunology
Volume93
Issue number1
Publication statusPublished - Jul-1993

    Keywords

  • PROSPECTIVE STUDY, SYSTEMIC LUPUS ERYTHEMATOSUS, NEPHRITIS, ANTI-DNA ANTIBODIES, ANTI-HS REACTIVITY, CROSS-REACTIVITY, DNA ANTIBODIES, CROSS-REACTIVITY, CIRCULATING DNA, NEPHRITIS, SULFATE, GLOMERULONEPHRITIS, LOCALIZATION, CLEARANCE, COMPLEXES, HISTONE

ID: 2012939