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High dietary sodium blunts affects of angiotensin-converting enzyme inhibition on vascular angiotensin I-to-angiotensin II conversion in rats

Kocks, M. J. A., Buikema, H., Gschwend, S., Boomsma, F., de Zeeuw, D. & Navis, G., Nov-2003, In : Journal of Cardiovascular Pharmacology. 42, 5, p. 601-6 6 p.

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High sodium intake blunts the efficacy of angiotensin (Ang)-converting enzyme (ACE) inhibition (ACEi), but the underlying mechanism is incompletely characterized. High sodium has been reported to increase vascular expression and vascular activity of ACE. To investigate whether high-dietary sodium-induced effects on vascular conversion of Ang I might be involved in the sodium-induced blunting of the response to ACEi, the authors studied the vasoconstrictor responses to Ang I and Ang II of isolated aortic rings from healthy rats on low dietary sodium (LS: 0.05% NaCl) and high dietary sodium (HS: 2.0% NaCl) after 3 weeks of ACEi (lisinopril 75 mg/L) or vehicle (CON). Blood pressure was similar in LS and HS in CON, but HS blunted the blood pressure response to ACEi. Functional conversion of Ang I was assessed as the difference in dose-response curves to Ang I and Ang II in parallel aortic rings. Sodium intake did not affect the dose-response curves to Ang I and Ang II in CON. In the ACEi groups, a significant difference was present between the curves for Ang I and Ang II on LS (deltaEC50, 6.7 nM; range, 2.2-13 nM; P < 0.01) but not on HS (deltaEC50: 1.3 nM; range, 0.0-4.1 nM, median [interquartile range], NS). Thus, HS blunts the ACEi-induced reduction of functional vascular Ang I conversion compared with LS. Whether the blunted functional vascular conversion is causally related to the blunted blood pressure response remains to be elucidated.

Original languageEnglish
Pages (from-to)601-6
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume42
Issue number5
Publication statusPublished - Nov-2003

    Keywords

  • Angiotensin I, Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Animals, Aorta, Thoracic, Dose-Response Relationship, Drug, In Vitro Techniques, Rats, Rats, Wistar, Sodium, Dietary

ID: 23714971