Het effect van de CBG-waarschuwing op de trend in SSRI-gebruik in Nederland van 1998 tot 2010Bijlsma, M. J., Oortgiesen, B. E., Beernink, R. H. J., Bos, J., Wilffert, B. & Hak, E., 21-Feb-2014, In : Pharmaceutisch Weekblad Wetenschappelijk Platform. 149, 8, p. 32-36 5 p.
Research output: Contribution to journal › Article › Academic › peer-review
OBJECTIVE: To determine the effect of the warning by the Dutch Medicines Evaluation Board (CBG) in 2004 concerning SSRI use by children on the trend of SSRI utilization in the Dutch population in the period 1998-2010. DESIGN: Interrupted time series analysis. METHODS: Yearly prevalence of SSRI utilization (excluding fluoxetine) was calculated for the age categories 12-18, 19-24, 25-49, 50-64 and 65-84 years. Regression was used to determine whether the trend in SSRI utilization after 2004 changed significantly from the trend before 2004. RESULTS: Prevalence in SSRI utilization in age groups 12-18, 19-24 and 25-49 years increased in the period 1998 to 2004 and started to decline after 2004 (P <0.001) until 2010. Prevalence in age categories 50-64 and 64-84 years increased in the period 1998 to 2004 and the increase in prevalence afterwards is not significantly different from 0. Prevalence of fluoxetine utilization declined throughout the study period. CONCLUSION: The CBG warning appears to strongly affect the trends in the utilization of SSRIs (excluding fluoxetine) in the Netherlands. It is noteworthy that the trends in SSRI utilization in age categories above 24 years, at which the warning was not aimed, significantly changed after 2004.
|Translated title of the contribution||The effect of the warning by the Dutch Medicines Evaluation Board on the trend in SSRI utilization in the Netherlands from 1998 to 2010|
|Number of pages||5|
|Journal||Pharmaceutisch Weekblad Wetenschappelijk Platform|
|Publication status||Published - 21-Feb-2014|
- serotonin uptake inhibitor, adolescent, adult, aged, article, child, child care, drug utilization, human, middle aged, Netherlands, prevalence, school child, very elderly, young adult