Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family StudyMan, T., Nolte, I. M., Jaju, D., Al-Anqoudi, Z. A. M., Muñoz, M. L., Hassan, M. O., Al-Yahyaee, S., Bayoumi, R. A., Comuzzie, A. G., Floras, J. S., van Roon, A. M., Riese, H., Albarwani, S. & Snieder, H., 13-Mar-2020, In : Journal of Hypertension. 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
OBJECTIVE: To more precisely and comprehensively estimate the genetic and environmental correlations between various indices of obesity and BP.
METHODS: We estimated heritability and genetic correlations of obesity indices with BP in the Oman family study (n = 1231). Ambulatory and office beat-to-beat BP was measured and mean values for SBP and DBP during daytime, sleep, 24-h and 10 min at rest were calculated. Different indices were used to quantify obesity and fat distribution: BMI, percentage of body fat (%BF), waist circumference and waist-to-height ratio (WHtR). SOLAR software was used to perform univariate and bivariate quantitative genetic analyses adjusting for age, age, sex, age-sex and age--sex interactions.
RESULTS: Heritabilities of BP ranged from 30.2 to 38.2% for ambulatory daytime, 16.8--21.4% for sleeping time, 32.1--40.4% for 24-h and 22--24.4% for office beat-to-beat measurements. Heritabilities for obesity indices were 67.8% for BMI, 52.2% for %BF, 37.3% for waist circumference and 37.9% for WHtR. All obesity measures had consistently positive phenotypic correlations with ambulatory and office beat-to-beat SBP and DBP (r-range: 0.14--0.32). Genetic correlations of obesity indices with SBP and DBP were higher than environmental correlations (rG: 0.16--0.50; rE: 0.01--0.31).
CONCLUSION: The considerable genetic overlap between a variety of obesity indices and both ambulatory and office beat-to-beat BP highlights the relevance of pleiotropic genes. Future GWAS analyses should discover the specific genes both influencing obesity indices and BP to help unravel their shared genetic background.
|Number of pages||7|
|Journal||Journal of Hypertension|
|Publication status||E-pub ahead of print - 13-Mar-2020|