Hemagglutinin-Mediated Membrane Fusion: A Biophysical Perspective

Boonstra, S., Blijleven, J. S., Roos, W. H., Onck, P. R., van der Giessen, E. & van Oijen, A. M., May-2018, In : Annual Review of Biophysics. 47

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  • Hemagglutinin-Mediated Membrane Fusion

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Influenza hemagglutinin (HA) is a viral membrane protein responsible for the initial steps of the entry of influenza virus into the host cell. It mediates binding of the virus particle to the host-cell membrane and catalyzes fusion of the viral membrane with that of the host. HA is therefore a major target in the development of antiviral strategies. The fusion of two membranes involves high activation barriers and proceeds through several intermediate states. Here, we provide a biophysical description of the membrane fusion process, relating its kinetic and thermodynamic properties to the large conformational changes taking place in HA and placing these in the context of multiple HA proteins working together to mediate fusion. Furthermore, we highlight the role of novel single-particle experiments and computational approaches in understanding the fusion process and their complementarity with other biophysical approaches. Expected final online publication date for the Annual Review of Biophysics Volume 47 is May 20, 2018. Please see for revised estimates.

Original languageEnglish
JournalAnnual Review of Biophysics
Early online date1-Mar-2018
Publication statusPublished - May-2018


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